There are 5 ways to get from Denver to Santee by plane, car, bus (Greyhound, Flixbus), train, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Charleston International Airport, drive
best- Fly from Denver (DEN) to Charleston International Airport (CHS)plane DEN - CHS
- Drive from Charleston-Airport-CHS to Santeecar
5h 54m$440–826Fly to Columbia, drive
cheapest- Fly from Denver (DEN) to Columbia (CAE)plane DEN - CAE
- Drive from Columbia-Airport-CAE to Santeecar
7h 46m$130–576Bus
- Take the bus from Denver Union Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Camdenbus
- Take the bus from Camden to Orangeburgbus
38h 58m$342–538Train, taxi (Amtrak)
- Take the train from Denver to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Denmark Amtrak Stationtrain
- Take the taxi from Denmark Amtrak Station to Santeetaxi
2d 2h$746–1,515Drive 1,630.5 mi
- Drive from Denver to Santeecar 1,630.5 mi
27h 14m$298–430
Denver (DEN) to Charleston International Airport (CHS) flights
Comparing Your Travel Options
The cheapest way to get from Denver to Santee is to fly and drive which costs $130 - $600 and takes 7h 46m.
The fastest way to get from Denver to Santee is to fly and drive which takes 5h 54m and costs $440 - $850.
No, there is no direct bus from Denver station to Santee. However, there are services departing from Denver Union Station and arriving at Orangeburg via St Louis Bus Station, Atlanta Bus Station and Camden. The journey, including transfers, takes approximately 38h 58m.
The distance between Denver and Santee is 1539 miles. The road distance is 1640 miles.
The best way to get from Denver to Santee without a car is to bus which takes 38h 58m and costs $340 - $550.
It takes approximately 5h 54m to get from Denver to Santee, including transfers.
Denver to Santee bus services, operated by Greyhound USA, depart from Denver Union Station.
Denver to Santee bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Santee is 2h ahead of Denver. It is currently 5:01 PM in Denver and 7:01 PM in Santee.
Yes, the driving distance between Denver to Santee is 1640 miles. It takes approximately 27h 14m to drive from Denver to Santee.
What companies run services between Denver, CO, USA and Santee, SC, USA?
You can take a bus from Denver Union Station to Santee via St Louis Bus Station, Atlanta Bus Station, Camden, and Orangeburg in around 38h 58m.
- Website
- delta.com
Flights from Denver to Charleston International Airport via Atlanta
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $140–650
Flights from Denver to Columbia via Atlanta
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $110–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Denver to Chicago Union Station
- Ave. Duration
- 18h 40m
- Frequency
- Once daily
- Estimated price
- $260–600
- Website
- Amtrak
Train from Chicago Union Station to Denmark Amtrak Station
- Ave. Duration
- 29h 50m
- Frequency
- Once daily
- Estimated price
- $340–750
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Denver Union Station to St Louis Bus Station
- Ave. Duration
- 16h 30m
- Frequency
- Twice daily
- Estimated price
- $130–220
- Website
- Greyhound
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $85–140
- Website
- Greyhound
Bus from Atlanta Bus Station to Camden
- Ave. Duration
- 5h
- Frequency
- Twice daily
- Estimated price
- $35–65
- Website
- Greyhound
Bus from Camden to Orangeburg
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $13–22
- Website
- Greyhound
- Ave. Duration
- 57 min
- Estimated price
- $140–180
Want to know more about travelling around United States
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Booking & Getting There
There are 41+ hotels available in Santee.








