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How to get fromDepew to Charlestonby plane, train (Amtrak), car, bus, or train

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There are 5 ways to get from Depew to Charleston by plane, train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS)plane plane BUF - CHS
    5h 26m
    $114–572

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    24h 37m
    $662–1,062

  3. Drive  863.9 mi

    1. Drive from Depew to Charlestoncar car 863.9 mi
    14h 47m
    $158–228

  4. Fly to Hilton Head Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Hilton Head Airport (HHH)plane plane BUF - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    6h 35m
    $115–477

  5. Bus, train

    1. Take the bus from Buffalo to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    26h 31m
    $456–766

Depew to Charleston by bus and train

Calendar14Weekly Services
Duration26h 31mAverage Duration
Ticket$456Cheapest Price
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Comparing Your Travel Options

Map of how to get from Depew to Charleston.ExpandLaunch map view
  • Distance: 716.6 mi
  • Duration: 5h 26m

What companies run services between Depew, NY, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS) every 2 hours. Alternatively, you can take a bus from Broadway & Meridian Street to Charleston via Dick Road & AMTRAK Station, Buffalo Depew Station, Ny Moynihan Train Hall At Penn Station, and Charleston Amtrak Station in around 24h 37m.

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