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How to get fromDes Moines Airport (DSM) to Florida Keysby plane, bus, train, shuttle, car, ferry, or taxi

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There are 8 ways to get from Des Moines Airport (DSM) to Florida Keys by plane, bus, train, shuttle, car, ferry, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    8h 15m
    $231–754

  2. Bus, train, shuttle

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    2d 15h
    $966–1,994

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 18h
    $710–1,589

  4. Drive 1,653.4 mi

    1. Drive from Des Moines Airport (DSM) to Florida Keyscar car 1,653.4 mi
    30h 37m
    $302–436

  5. Fly to Miami International Airport, shuttle

    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)plane plane DSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 59m
    $329–952

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 9m
    $355–998

  7. Fly to Ft. Myers, ferry

    1. Fly from Des Moines (DSM) to Ft. Myers (RSW)plane plane DSM - RSW
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    11h 33m
    $353–1,001

  8. Fly to Punta Gorda Airport, taxi, ferry

    1. Fly from Des Moines (DSM) to Punta Gorda Airport (PGD)plane plane DSM - PGD
    2. Take the taxi from Punta Gorda Airport (PGD) to Beach Park & Ridetaxi taxi
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    11h 40m
    $403–1,013

Des Moines (DSM) to Key West International Airport (EYW) flights

Calendar38Weekly Planes
Duration7h 11mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from Des Moines Airport (DSM) to Florida Keys.ExpandLaunch map view
  • Distance: 1,378.6 mi
  • Duration: 8h 15m

What companies run services between Des Moines Airport (DSM), USA and Florida Keys, FL, USA?

American Airlines, Delta, and United Airlines fly from Des Moines (DSM) to Key West International Airport (EYW) 5 times a day.

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