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How to get fromDes Moines Airport (DSM) to Saint Charlesby plane, bus (Greyhound), rideshare, car, or train

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There are 5 ways to get from Des Moines Airport (DSM) to Saint Charles by plane, bus (Greyhound), rideshare, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    4h 55m
    $127–688
  2. Drive 310.8 mi

    cheapest
    1. Drive from Des Moines Airport (DSM) to Saint Charlescar car 310.8 mi
    6h 32m
    $57–82
  3. Bus (Greyhound)

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    11h 24m
    $124–335
  4. Airport Transfer

    1. Take the rideshare from Des Moines-DSM to Saint Charlesrideshare rideshare 310.8 mi
    6h 32m
  5. Fly to Abraham Lincoln Capital Airport, train

    1. Fly from Des Moines (DSM) to Abraham Lincoln Capital Airport (SPI)plane plane DSM - SPI
    2. Take the train from Springfield to St. Louistrain train
    8h 1m
    $125–543

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar134Weekly Planes
Duration5h 27mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

What companies run services between Des Moines Airport (DSM), USA and Saint Charles, MO, USA?

Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Des Moines to St Louis Bus Station once daily. Tickets cost $60–120 and the journey takes 8h 20m.

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