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How to get fromDes Moines to Ashevilleby plane, bus (Greyhound), bus, train, or car

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There are 9 ways to get from Des Moines to Asheville by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Asheville Regional Airport

    best
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    6h 1m
    $100–444

  2. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    29h 25m
    $206–320

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    34h 38m
    $536–865

  4. Drive  892.2 mi

    1. Drive from Des Moines to Ashevillecar car 892.2 mi
    16h 25m
    $163–236

  5. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Ashevillecar car
    5h 24m
    $150–690

  6. Fly to Mcghee Tyson Airport, drive

    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Ashevillecar car
    6h 38m
    $209–1,003

  7. Bus via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    29h 50m
    $184–317

  8. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    39h 21m
    $679–1,147

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    40h 19m
    $741–1,259

Des Moines to Asheville by bus (Greyhound)

Calendar7Weekly Buses
Duration29h 25mAverage Duration
Ticket$206Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Asheville.ExpandLaunch map view
  • Distance: 752.8 mi
  • Duration: 6h 1m

What companies run services between Des Moines, IA, USA and Asheville, NC, USA?

Delta, American Airlines, and two other airlines fly from Des Moines (DSM) to Asheville Regional Airport (AVL) every 2 hours. Alternatively, you can take a bus from Des Moines to Asheville, NC via Indianapolis Union Station, Columbus, and Winston Salem(Trans Center) in around 29h 25m.

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