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How to get fromDes Moines to Ashlandby plane, bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Des Moines to Ashland by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tri-State Airport

    best
    1. Fly from Des Moines (DSM) to Tri-State Airport (HTS)plane plane DSM - HTS
    5h 23m
    $191–750

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Ashland Bus Stationbus bus
    18h 30m
    $108–236

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train Cardinal
    17h 10m
    $155–311

  4. Drive 705 mi

    1. Drive from Des Moines to Ashlandcar car 705 mi
    12h 33m
    $129–186

  5. Fly to Blue Grass Airport, drive

    1. Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane plane DSM - LEX
    2. Drive from Lexington-Airport-LEX to Ashlandcar car
    6h 38m
    $260–1,256

  6. Fly to Yeager Airport, train

    1. Fly from Des Moines (DSM) to Yeager Airport (CRW)plane plane DSM - CRW
    2. Take the train from Charleston Station to Ashland Amtrak Stationtrain train
    7h 54m
    $183–783

  7. Fly to John Glenn Columbus International Airport, bus

    1. Fly from Des Moines (DSM) to John Glenn Columbus International Airport (CMH)plane plane DSM - CMH
    2. Take the bus from Columbus to Ashland Bus Stationbus bus
    8h 7m
    $180–951

Des Moines to Ashland by bus and train

Calendar3Weekly Services
Duration17h 10mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Ashland.ExpandLaunch map view
  • Distance: 643.2 mi
  • Duration: 5h 23m

What companies run services between Des Moines, IA, USA and Ashland, KY, USA?

American Airlines flies from Des Moines (DSM) to Tri-State Airport (HTS) twice daily. Alternatively, you can take a bus from Des Moines to Ashland Bus Station via Indianapolis Union Station and Columbus in around 18h 30m.

Airlines
Train operators
Bus operators

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