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How to get fromDes Moines to Bryson Cityby plane, car, bus, or train

Find Transport to Bryson City

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There are 9 ways to get from Des Moines to Bryson City by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Asheville Regional Airport, drive

    best
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Bryson Citycar car
    5h 33m
    $160–690

  2. Bus, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the bus from Indianapolis to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    29h 55m

  3. Bus, train, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    35h 59m

  4. Drive 891.3 mi

    1. Drive from Des Moines to Bryson Citycar car 891.3 mi
    16h 7m
    $163–235

  5. Fly to Mcghee Tyson Airport, drive

    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Bryson Citycar car
    6h 49m
    $262–1,243

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Bryson Citycar car
    6h 39m
    $240–1,056

  7. Bus, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the bus from Chicago to N Wilson Rd & Ferrell Pl - Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the bus from Charlotte Bus Station to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Bryson Citycar car
    32h 15m

  8. Bus, train, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    39h 43m

  9. Bus, train, drive via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Bryson Citycar car
    41h 35m

Des Moines (DSM) to Asheville Regional Airport (AVL) flights

Calendar79Weekly Planes
Duration5h 29mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Bryson City.ExpandLaunch map view
  • Distance: 809.5 mi
  • Duration: 5h 33m

What companies run services between Des Moines, IA, USA and Bryson City, NC, USA?

There is no direct connection from Des Moines to Bryson City. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Asheville Regional Airport (AVL), then drive to Bryson City. Alternatively, you can take a bus from Des Moines to Bryson City via Indianapolis, Indianapolis, Columbus, S 3Rd St & E Town St, E Livingston Ave & Macon Aly, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 29h 55m.

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