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How to get fromDes Moines to Bryson Cityby plane, car, bus, train, or shuttle

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There are 10 ways to get from Des Moines to Bryson City by plane, car, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Asheville Regional Airport, drive

    best
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Bryson Citycar car
    5h 52m
    $111–462

  2. Bus, drive (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    30h 41m
    $218–337

  3. Bus, train, drive

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    35h 54m
    $548–882

  4. Drive  891.2 mi

    1. Drive from Des Moines to Bryson Citycar car 891.2 mi
    16h 7m
    $163–235

  5. Fly to Mcghee Tyson Airport, drive

    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Bryson Citycar car
    6h 17m
    $203–995

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Bryson Citycar car
    6h 24m
    $161–708

  7. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Des Moines (DSM) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane DSM - ATL
    2. Drive from Atlanta-Airport-ATL to Bryson Citycar car
    5h 32m
    $134–538

  8. Bus, shuttle, drive

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the bus from Charlotte to Boonebus bus
    5. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Bryson Citycar car
    36h 45m
    $385–527

  9. Bus, train, drive via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Bryson Citycar car
    40h 38m
    $690–1,164

  10. Bus, train, drive via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Bryson Citycar car
    41h 35m
    $758–1,276

Des Moines (DSM) to Asheville Regional Airport (AVL) flights

Calendar75Weekly Planes
Duration5h 36mAverage Duration
Ticket$81Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Bryson City.ExpandLaunch map view
  • Distance: 809.5 mi
  • Duration: 5h 52m

What companies run services between Des Moines, IA, USA and Bryson City, NC, USA?

There is no direct connection from Des Moines to Bryson City. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Asheville Regional Airport (AVL), then drive to Bryson City. Alternatively, you can take a bus from Des Moines to Bryson City via Indianapolis Union Station, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 30h 41m.

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