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How to get fromDes Moines to Buffaloby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Des Moines to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane plane DSM - BUF
    5h 2m
    $164–851

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 10m
    $100–222

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 18m
    $186–396

  4. Drive  848.9 mi

    1. Drive from Des Moines to Buffalocar car 848.9 mi
    14h 14m
    $155–224

  5. Fly to Rochester, bus

    1. Fly from Des Moines (DSM) to Rochester (ROC)plane plane DSM - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 36m
    $248–1,164

  6. Fly to Toronto Pearson International Airport, bus

    1. Fly from Des Moines (DSM) to Toronto Pearson International Airport (YYZ)plane plane DSM - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    8h 26m
    $118–525

  7. Bus via Akron

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Robert K Pfaff Transit Center - Akronbus bus
    3. Take the bus from Akron to Buffalobus bus
    21h
    $128–237

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    21h 9m
    $204–596

Des Moines to Buffalo by bus

Calendar14Weekly Buses
Duration19h 10mAverage Duration
Ticket$100Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Buffalo.ExpandLaunch map view
  • Distance: 784.7 mi
  • Duration: 5h 2m

What companies run services between Des Moines, IA, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Des Moines to Buffalo, NY via Chicago and Cleveland, OH in around 19h 10m.

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