There are 7 ways to get from Des Moines to Cape Cod by plane, bus, train, bus (Greyhound, Flixbus), car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Boston Logan Airport, bus
best- Fly from Des Moines (DSM) to Boston Logan Airport (BOS)plane DSM - BOS
- Take the bus from Logan International Airport to Hyannis Transportation Centerbus
6h 53m$147–613Bus, train
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Bostontrain
- Take the bus from Boston South Buses to Hyannis Transportation Centerbus
33h 51m$637–1,023Bus
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to New York Midtownbus
- Take the bus from New York Midtown to Bostonbus
- Take the bus from Boston South Buses to Hyannis Transportation Centerbus
37h 4m$267–413Drive 1,345.5 mi
- Drive from Des Moines to Cape Codcar 1,345.5 mi
23h 11m$246–355Fly to Barnstable Municipal Airport
- Fly from Des Moines (DSM) to Barnstable Municipal Airport (HYA)plane DSM - HYA
7h 26m$150–674Fly to Provincetown Municipal Airport, taxi
- Fly from Des Moines (DSM) to Provincetown Municipal Airport (PVC)plane DSM - PVC
- Take the taxi from Provincetown Municipal Airport (PVC) to Cape Codtaxi
6h 1m$289–803Bus, train via Galesburg
- Take the bus from Des Moines to Galesburgbus
- Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Bostontrain
- Take the bus from Boston to Hyannisbus
35h 14m$686–1,120
Des Moines to Cape Cod by bus, foot, and train
Comparing Your Travel Options
The cheapest way to get from Des Moines to Cape Cod is to drive which costs $240 - $360 and takes 23h 11m.
The fastest way to get from Des Moines to Cape Cod is to fly and taxi which takes 6h 1m and costs $280 - $850.
No, there is no direct bus from Des Moines to Cape Cod. However, there are services departing from Des Moines and arriving at Town Hall Lawton Bus Shelter via Chicago Bus Station, New York Midtown, Boston South Buses and Hyannis Transportation Center. The journey, including transfers, takes approximately 37h 4m.
The distance between Des Moines and Cape Cod is 1258 miles. The road distance is 1353.4 miles.
The best way to get from Des Moines to Cape Cod without a car is to bus and train which takes 33h 51m and costs $600 - $1,100.
It takes approximately 6h 53m to get from Des Moines to Cape Cod, including transfers.
Des Moines to Cape Cod bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Cape Cod is to bus which takes 37h 4m and costs $260 - $420. Alternatively, you can fly, which costs $150 - $700 and takes 7h 26m.
Des Moines to Cape Cod bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Yes, the driving distance between Des Moines to Cape Cod is 1353 miles. It takes approximately 23h 11m to drive from Des Moines to Cape Cod.
What companies run services between Des Moines, IA, USA and Cape Cod, MA, USA?
You can take a bus from Des Moines to Town Hall Lawton Bus Shelter via Chicago Bus Station, New York Midtown, Boston, Boston South Buses, and Hyannis Transportation Center in around 37h 4m. Alternatively, American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Barnstable Municipal Airport (HYA) twice daily.
- Website
- capeair.com
Flights from Des Moines to Barnstable Municipal Airport via Boston Logan Airport
- Ave. Duration
- 7h 20m
- When
- Friday
- Estimated price
- $140–700
Flights from Des Moines to Provincetown Municipal Airport via Boston Logan Airport
- Ave. Duration
- 4h 41m
- When
- Friday
- Estimated price
- $120–600
Flights from Des Moines to Provincetown Municipal Airport via Chicago Midway, Boston Logan Airport
- Ave. Duration
- 6h 36m
- When
- Tuesday and Wednesday
- Estimated price
- $120–600
Flights from Des Moines to Provincetown Municipal Airport via Detroit, Boston Logan Airport
- Ave. Duration
- 7h 25m
- When
- Every day
- Estimated price
- $120–600
Flights from Des Moines to Provincetown Municipal Airport via Minneapolis, Boston Logan Airport
- Ave. Duration
- 7h 43m
- When
- Friday and Thursday
- Estimated price
- $130–650
Flights from Des Moines to Provincetown Municipal Airport via New York La Guardia, Boston Logan Airport
- Ave. Duration
- 6h 54m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $120–600
Flights from Des Moines to Provincetown Municipal Airport via Philadelphia, Boston Logan Airport
- Ave. Duration
- 8h 4m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–600
- Website
- aa.com
Flights from Des Moines to Boston Logan Airport via Chicago O'Hare
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $100–550
Flights from Des Moines to Boston Logan Airport via Philadelphia
- Ave. Duration
- 5h 13m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $110–550
Flights from Des Moines to Barnstable Municipal Airport via Philadelphia
- Ave. Duration
- 5h 6m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $140–700
Flights from Des Moines to Barnstable Municipal Airport via New York La Guardia
- Ave. Duration
- 5h 54m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
Flights from Des Moines to Barnstable Municipal Airport via Chicago O'Hare
- Ave. Duration
- 5h 40m
- When
- Saturday
- Estimated price
- $130–650
Flights from Des Moines to Barnstable Municipal Airport via Reagan Washington
- Ave. Duration
- 9h 21m
- When
- Sunday
- Estimated price
- $140–700
- Website
- southwest.com
Flights from Des Moines to Boston Logan Airport via Chicago Midway
- Ave. Duration
- 4h 41m
- When
- Monday, Tuesday, Wednesday, and Saturday
- Estimated price
- $100–550
- Website
- united.com
Flights from Des Moines to Boston Logan Airport via Chicago O'Hare
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $100–550
- Website
- delta.com
Flights from Des Moines to Boston Logan Airport via Detroit
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $100–550
- Website
- allegiantair.com
Flights from Des Moines to Boston Logan Airport
- Ave. Duration
- 2h 48m
- When
- Monday and Friday
- Estimated price
- $100–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Boston
- Ave. Duration
- 22h 2m
- Frequency
- Once daily
- Estimated price
- $550–900
- Website
- Amtrak
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $85–140
- Website
- Amtrak
Train from Chicago Union Station to Boston
- Ave. Duration
- 22h 2m
- Frequency
- Once daily
- Estimated price
- $550–900
- Website
- Amtrak
- Phone
- +1 (508) 746-0378
- [email protected]
- Website
- Plymouth & Brockton
Bus from Logan International Airport to Hyannis Transportation Center
- Ave. Duration
- 2h 15m
- Frequency
- Hourly
- Estimated price
- $28–40
- Website
- Plymouth & Brockton
- One Way - Adult
- $28–40
Bus from Boston South Buses to Hyannis Transportation Center
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Bus from Boston South Buses to Hyannis Transportation Center
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Website
- Greyhound
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Website
- Greyhound
Bus from Des Moines to Galesburg
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Chicago Bus Station to New York Midtown
- Ave. Duration
- 20h 10m
- Frequency
- Twice daily
- Estimated price
- $150–240
- Schedules at
- Flixbus USA
Bus from New York Midtown to Boston
- Ave. Duration
- 4h 20m
- Frequency
- Hourly
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from Boston to Hyannis
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- $14–25
- Website
- Peter Pan
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
There are 861+ hotels available in Cape Cod.











