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How to get fromDes Moines to Cape Girardeauby plane, taxi, bus (Greyhound), or car

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There are 6 ways to get from Des Moines to Cape Girardeau by plane, taxi, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barkley Regional Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Barkley Regional Airport (PAH)plane plane DSM - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    6h 51m
    $268–791

  2. Drive 428.5 mi

    cheapest
    1. Drive from Des Moines to Cape Girardeaucar car 428.5 mi
    8h 19m
    $79–113

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus Greyhound US1173
    11h 29m
    $88–164

  4. Fly to Cape Girardeau Municipal Airport

    1. Fly from Des Moines (DSM) to Cape Girardeau Municipal Airport (CGI)plane plane DSM - CGI
    5h 20m
    $301–1,149

  5. Fly to Williamson County Regional Airport, taxi

    1. Fly from Des Moines (DSM) to Williamson County Regional Airport (MWA)plane plane DSM - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    5h 20m
    $258–781

  6. Bus via Iowa City

    1. Take the bus from Des Moines to Iowa Citybus bus
    2. Take the bus from Iowa City to Saint Louisbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 14m

Des Moines (DSM) to Barkley Regional Airport (PAH) flights

Calendar21Weekly Planes
Duration6h 26mAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Cape Girardeau.ExpandLaunch map view
  • Distance: 473.2 mi
  • Duration: 6h 51m

What companies run services between Des Moines, IA, USA and Cape Girardeau, MO, USA?

You can take a bus from Des Moines to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 11h 29m. Alternatively, United Airlines, Corporate Flight Management Inc, and American Airlines fly from Des Moines (DSM) to Cape Girardeau Municipal Airport (CGI) 3 times a day.

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