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How to get fromDes Moines to Charlestonby plane, bus, train, or car

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There are 5 ways to get from Des Moines to Charleston by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport

    best
    1. Fly from Des Moines (DSM) to Charleston International Airport (CHS)plane plane DSM - CHS
    6h 11m
    $170–773

  2. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    38h 4m
    $512–1,060

  3. Bus, train via Newark

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train
    46h 24m
    $415–837

  4. Drive 1,158.9 mi

    1. Drive from Des Moines to Charlestoncar car 1,158.9 mi
    20h 40m
    $212–306

  5. Fly to Hilton Head Airport, drive

    1. Fly from Des Moines (DSM) to Hilton Head Airport (HHH)plane plane DSM - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 32m
    $176–748

Des Moines to Charleston by bus and train

Calendar7Weekly Services
Duration46h 24mAverage Duration
Ticket$415Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Charleston.ExpandLaunch map view
  • Distance: 977.3 mi
  • Duration: 6h 11m

What companies run services between Des Moines, IA, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Charleston International Airport (CHS) hourly.

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