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How to get fromDes Moines to Charlotteby plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Des Moines to Charlotte by plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    3h 16m
    $161–774

  2. Bus via Carbondale

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Downtown to Charlotte Bus Stationbus bus
    25h 44m
    $165–323

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    36h 38m
    $392–838

  4. Drive 1,029.4 mi

    1. Drive from Des Moines to Charlottecar car 1,029.4 mi
    17h 40m
    $188–272

  5. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    26h
    $164–325

  6. Bus, train via Ironville

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland to Wythevillebus bus
    4. Take the bus from Wytheville to Charlotte Bus Stationbus bus
    26h 5m
    $172–403

  7. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    37h 36m
    $409–915

Des Moines to Charlotte by bus and subway

Calendar4Weekly Services
Duration25h 44mAverage Duration
Ticket$165Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Charlotte.ExpandLaunch map view
  • Distance: 827.8 mi
  • Duration: 3h 16m

What companies run services between Des Moines, IA, USA and Charlotte, NC, USA?

American Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT) every 2 hours. Alternatively, you can take a bus from Des Moines to Charlotte Bus Station via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, Atlanta Bus Station, Garnett Station, Civic Center Station, and Atlanta Downtown in around 25h 44m.

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