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How to get fromDes Moines to Charlotteby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Des Moines to Charlotte by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    3h 8m
    $142–726

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    26h 55m
    $135–263

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Charlotte Amtrak Stationtrain train
    32h 23m
    $553–902

  4. Drive  1,029.4 mi

    1. Drive from Des Moines to Charlottecar car 1,029.4 mi
    17h 40m
    $188–272

  5. Bus via Atlanta

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    27h 10m
    $213–337

  6. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    36h 38m
    $700–1,178

  7. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    37h 36m
    $767–1,295

Des Moines to Charlotte by bus

Calendar7Weekly Buses
Duration26h 55mAverage Duration
Ticket$135Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Charlotte.ExpandLaunch map view
  • Distance: 827.8 mi
  • Duration: 3h 8m

What companies run services between Des Moines, IA, USA and Charlotte, NC, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT) every 4 hours. Alternatively, you can take a bus from Des Moines to Charlotte via Chicago and Columbus in around 26h 55m.

Airlines
Train operators
Bus operators

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