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How to get fromDes Moines to Durhamby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Des Moines to Durham by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Raleigh-Durham International Airport

    best
    1. Fly from Des Moines (DSM) to Raleigh-Durham International Airport (RDU)plane plane DSM - RDU
    5h 46m
    $174–777

  2. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Durhambus bus
    29h 5m
    $205–410

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Carytrain train Floridian
    34h 27m
    $408–802

  4. Drive 1,053.4 mi

    1. Drive from Des Moines to Durhamcar car 1,053.4 mi
    18h 17m
    $193–278

  5. Fly to Piedmont Triad International Airport, train

    1. Fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO)plane plane DSM - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 47m
    $275–1,196

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain train
    7h 19m
    $257–1,077

  7. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Durham Amtrak Stationtrain train
    34h 56m
    $440–886

Des Moines to Durham by bus

Calendar7Weekly Buses
Duration29h 5mAverage Duration
Ticket$205Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Durham.ExpandLaunch map view
  • Distance: 913.3 mi
  • Duration: 5h 46m

What companies run services between Des Moines, IA, USA and Durham, NC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Raleigh-Durham International Airport (RDU) hourly. Alternatively, you can take a bus from Des Moines to Durham via St Louis Bus Station and Atlanta Bus Station in around 29h 5m.

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