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How to get fromDes Moines to Durhamby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Des Moines to Durham by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Boston Logan Airport, train

    best
    1. Fly from Des Moines (DSM) to Boston Logan Airport (BOS)plane plane DSM - BOS
    2. Take the train from Woburn Amtrak Station to Durham Stationtrain train
    5h 58m
    $193–765

  2. Fly to Theodore Francis Green State Airport, train

    cheapest
    1. Fly from Des Moines (DSM) to Theodore Francis Green State Airport (PVD)plane plane DSM - PVD
    2. Take the train from TF Green Airport to Rugglestrain train
    3. Take the train from Boston to Durham Stationtrain train
    9h 56m
    $160–635

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Bostontrain train
    3. Take the train from Boston to Durham Stationtrain train
    32h 41m
    $404–844

  4. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York Midtown to Portsmouth Bus Stopbus bus
    34h 54m
    $239–432

  5. Drive 1,301.5 mi

    1. Drive from Des Moines to Durhamcar car 1,301.5 mi
    23h 19m
    $238–344

  6. Fly to Portland, train

    1. Fly from Des Moines (DSM) to Portland (PWM)plane plane DSM - PWM
    2. Take the train from Portland to Durham Stationtrain train
    8h 22m
    $219–914

  7. Fly to Manchester Airport, bus, train

    1. Fly from Des Moines (DSM) to Manchester Airport (MHT)plane plane DSM - MHT
    2. Take the bus from Boston Manchester Airport to Bostonbus bus
    3. Take the train from Boston to Durham Stationtrain train
    9h 56m
    $208–834

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bostontrain train
    4. Take the train from Boston to Durham Stationtrain train
    33h 52m
    $435–918

Des Moines to Durham by bus, foot, train, and subway

Calendar7Weekly Services
Duration32h 41mAverage Duration
Ticket$404Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Durham.ExpandLaunch map view
  • Distance: 1,232.1 mi
  • Duration: 5h 58m

What companies run services between Des Moines, IA, USA and Durham, NH, USA?

You can take a bus from Des Moines to Durham Station via Chicago Bus Station, New York Midtown, Portsmouth Bus Stop, Hanover Station, Dover Transportation Center, and Dover in around 34h 54m.

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