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How to get fromDes Moines to Edwardsvilleby plane, taxi, bus (Greyhound), bus, train, or car

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There are 7 ways to get from Des Moines to Edwardsville by plane, taxi, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lambert–St. Louis International Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the taxi from St-Louis-Airport-STL to Edwardsvilletaxi taxi
    4h 29m
    $199–808

  2. Drive  325.3 mi

    cheapest
    1. Drive from Des Moines to Edwardsvillecar car 325.3 mi
    7h 24m
    $60–86

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    9h 1m
    $138–202

  4. Bus, train via Kansas City

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    11h 7m
    $145–273

  5. Fly to Abraham Lincoln Capital Airport, train

    1. Fly from Des Moines (DSM) to Abraham Lincoln Capital Airport (SPI)plane plane DSM - SPI
    2. Take the train from Springfield to Alton Stationtrain train
    7h 1m
    $159–594

  6. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus Greyhound US0157S
    2. Take the train from Bloomington-Normal to Alton Stationtrain train Texas Eagle / ...
    9h 52m
    $110–191

  7. Bus, train #2

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the train from Springfield to Alton Stationtrain train
    10h 13m
    $112–175

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar149Weekly Planes
Duration5h 15mAverage Duration
Ticket$116Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Edwardsville.ExpandLaunch map view
  • Distance: 295.5 mi
  • Duration: 4h 29m

What companies run services between Des Moines, IA, USA and Edwardsville, IL, USA?

You can take a bus from Des Moines to Edwardsville via Kansas City, Kansas City Bus Station, and St Louis Bus Station in around 9h 1m.

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