Rome2Rio

How to get fromDes Moines to Florenceby plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Find Transport to Florence

See all options

There are 6 ways to get from Des Moines to Florence by plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Florence Regional Airport (FLO)plane plane DSM - FLO
    5h 5m
    $168–734

  2. Bus via Carbondale

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    27h 45m
    $194–390

  3. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Florence Stationtrain train
    36h 34m
    $457–950

  4. Drive 1,126.2 mi

    1. Drive from Des Moines to Florencecar car 1,126.2 mi
    20h 9m
    $206–297

  5. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    28h 20m
    $194–380

  6. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    37h 28m
    $450–956

Des Moines to Florence by bus

Calendar5Weekly Buses
Duration27h 45mAverage Duration
Ticket$194Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Florence.ExpandLaunch map view
  • Distance: 920.4 mi
  • Duration: 5h 5m

What companies run services between Des Moines, IA, USA and Florence, SC, USA?

American Airlines flies from Des Moines (DSM) to Florence Regional Airport (FLO) 4 times a day. Alternatively, you can take a bus from Des Moines to Florence Bus Station via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, and Atlanta Bus Station in around 27h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers