There are 6 ways to get from Des Moines to Florence Station by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Des Moines (DSM) to Florence Regional Airport (FLO)plane DSM - FLO
5h 5m$158–683Bus via Carbondale
- Take the bus from Des Moines to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus
- Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Florence Bus Stationbus
27h 59m$193–368Bus, train via Galesburg
- Take the bus from Des Moines to Galesburgbus
- Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain
- Take the train from Petersburg Amtrak Station to Florence Stationtrain
36h 34m$446–949Drive 1,126.7 mi
- Drive from Des Moines to Florence Stationcar 1,126.7 mi
20h 10m$206–297Bus
- Take the bus from Des Moines to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Florence Bus Stationbus
28h 44m$193–363Bus, train
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Raleigh Union Stationtrain
- Take the train from Raleigh Union Station to Selma Stationtrain
- Take the train from Selma Station to Florence Stationtrain
37h 28m$439–954
Des Moines to Florence Station by bus and train
Questions & Answers
The cheapest way to get from Des Moines to Florence Station is to bus which costs $190 - $370 and takes 28h 44m.
The fastest way to get from Des Moines to Florence Station is to fly which takes 5h 5m and costs $150 - $700.
No, there is no direct bus from Des Moines to Florence Station station. However, there are services departing from Des Moines and arriving at Florence Bus Station via St Louis Bus Station, Carbondale Intermodal Station and Atlanta Bus Station. The journey, including transfers, takes approximately 27h 59m.
The distance between Des Moines and Florence Station is 926 miles. The road distance is 1133.2 miles.
The best way to get from Des Moines to Florence Station without a car is to bus via Carbondale which takes 27h 59m and costs $190 - $370.
It takes approximately 5h 5m to get from Des Moines to Florence Station, including transfers.
Des Moines to Florence Station bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Florence Station is to fly which takes 5h 5m and costs $150 - $700. Alternatively, you can bus via Carbondale, which costs $190 - $370 and takes 27h 59m.
Des Moines to Florence Station bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Florence Station is 1h ahead of Des Moines. It is currently 10:09 PM in Des Moines and 11:09 PM in Florence Station.
What companies run services between Des Moines, IA, USA and Florence Station, SC, USA?
American Airlines flies from Des Moines (DSM) to Florence Regional Airport (FLO) 4 times a day. Alternatively, you can take a bus from Des Moines to Florence Station via St Louis Bus Station, Carbondale Intermodal Station, Atlanta Bus Station, and Florence Bus Station in around 27h 59m.
- Website
- aa.com
Flights from Des Moines to Florence Regional Airport via Charlotte
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $130–650
Flights from Des Moines to Florence Regional Airport via Chicago O'Hare, Charlotte
- Ave. Duration
- 7h 34m
- When
- Every day
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $50–110
- Website
- Amtrak
Train from Chicago Union Station to Petersburg Amtrak Station
- Ave. Duration
- 21h 1m
- Frequency
- Once daily
- Estimated price
- $280–600
- Website
- Amtrak
Train from Petersburg Amtrak Station to Florence Station
- Ave. Duration
- 5h 8m
- Frequency
- Twice daily
- Estimated price
- $85–180
- Website
- Amtrak
Train from Chicago Union Station to Raleigh Union Station
- Ave. Duration
- 24h 1m
- Frequency
- Once daily
- Estimated price
- $340–750
- Website
- Amtrak
Train from Raleigh Union Station to Selma Station
- Ave. Duration
- 33 min
- Frequency
- Once daily
- Estimated price
- $9–19
- Website
- Amtrak
Train from Selma Station to Florence Station
- Ave. Duration
- 2h 40m
- Frequency
- Once daily
- Estimated price
- $40–90
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 20m
- Frequency
- Twice daily
- Estimated price
- $60–120
- Website
- Greyhound
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- 4 times a day
- Estimated price
- $45–85
- Website
- Greyhound
Bus from Des Moines to Galesburg
- Ave. Duration
- 4h 30m
- Frequency
- Twice daily
- Estimated price
- $30–60
- Website
- Greyhound
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 20m
- Frequency
- Twice daily
- Estimated price
- $60–120
- Website
- Greyhound
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Twice daily
- Estimated price
- $85–160
- Website
- Greyhound
Bus from Atlanta Bus Station to Florence Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- 4 times a day
- Estimated price
- $45–85
- Website
- Greyhound
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 5 times a day
- Estimated price
- $50–95
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $15–26
- Schedules at
- Flixbus USA
Bus from Carbondale Intermodal Station to Atlanta Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $70–120
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h
- Frequency
- Once daily
- Estimated price
- $90–150
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- Amtrak
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More Questions & Answers
Yes, the driving distance between Des Moines to Florence Station is 1133 miles. It takes approximately 20h 10m to drive from Des Moines to Florence Station.
There are 49+ hotels available in Florence Station.








