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How to get fromDes Moines to Floridaby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 8 ways to get from Des Moines to Florida by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tallahassee

    best
    1. Fly from Des Moines (DSM) to Tallahassee (TLH)plane plane DSM - TLH
    4h 48m
    $200–848

  2. Fly to Jacksonville

    cheapest
    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    6h 27m
    $169–774

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    28h 49m
    $206–413

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    43h 56m
    $553–1,199

  5. Drive 1,177.5 mi

    1. Drive from Des Moines to Jacksonvillecar car 1,177.5 mi
    22h 14m
    $215–311

  6. Fly to Fort Lauderdale–Hollywood International Airport

    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    4h 8m
    $200–874

  7. Fly to Orlando Sanford

    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    3h 37m
    $228–846

  8. Fly to Saint Petersburg–Clearwater International Airport

    1. Fly from Des Moines (DSM) to Saint Petersburg–Clearwater International Airport (PIE)plane plane DSM - PIE
    4h 52m
    $174–777

Des Moines to Florida by bus

Calendar7Weekly Buses
Duration28h 49mAverage Duration
Ticket$206Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Florida.ExpandLaunch map view
  • Distance: 940.5 mi
  • Duration: 4h 48m

What companies run services between Des Moines, IA, USA and Florida, USA?

Delta and American Airlines fly from Des Moines (DSM) to Tallahassee (TLH) every 4 hours. Alternatively, you can take a bus from Des Moines to Newnan St + Ashley St via St Louis Bus Station, Atlanta Bus Station, Jacksonville, and JRTC Bay J in around 28h 49m.

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