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How to get fromDes Moines to Florida Keysby plane, bus, train, shuttle, or car

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There are 6 ways to get from Des Moines to Florida Keys by plane, bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    7h 46m
    $235–765

  2. Bus, train, shuttle

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    4. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    2d 13h
    $908–1,782

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 17h
    $672–1,321

  4. Drive 1,652.7 mi

    1. Drive from Des Moines to Florida Keyscar car 1,652.7 mi
    30h 24m
    $302–436

  5. Fly to Miami International Airport, shuttle

    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)plane plane DSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 11m
    $330–955

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 22m
    $370–1,075

Des Moines to Florida Keys by bus, train, taxi, and foot

Calendar7Weekly Services
Duration2d 17hAverage Duration
Ticket$672Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Florida Keys.ExpandLaunch map view
  • Distance: 1,385.4 mi
  • Duration: 7h 46m

What companies run services between Des Moines, IA, USA and Florida Keys, FL, USA?

Allegiant Air, American Airlines, and two other airlines fly from Des Moines (DSM) to Key West International Airport (EYW) every 4 hours.

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Train operators
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