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How to get fromDes Moines to Fort Myersby plane, bus (Greyhound, Flixbus), bus, train, car, or taxi

Find Transport to Fort Myers

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There are 7 ways to get from Des Moines to Fort Myers by plane, bus (Greyhound, Flixbus), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ft. Myers

    best
    1. Fly from Des Moines (DSM) to Ft. Myers (RSW)plane plane DSM - RSW
    5h 9m
    $182–828

  2. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    36h 5m
    $247–403

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Tampatrain train
    3. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    2d 5h
    $515–1,216

  4. Drive  1,422.9 mi

    1. Drive from Des Moines to Fort Myerscar car 1,422.9 mi
    25h 54m
    $260–376

  5. Fly to Punta Gorda Airport, taxi

    1. Fly from Des Moines (DSM) to Punta Gorda Airport (PGD)plane plane DSM - PGD
    2. Take the taxi from Punta Gorda Airport (PGD) to Fort Myerstaxi taxi
    3h 43m
    $219–813

  6. Fly to Sarasota–Bradenton International Airport, bus

    1. Fly from Des Moines (DSM) to Sarasota–Bradenton International Airport (SRQ)plane plane DSM - SRQ
    2. Take the bus from Sarasota Cattlemen Transfer Center to Fort Myers Bus Stopbus bus
    6h 14m
    $251–1,143

  7. Bus, train via New Orleans

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Fort Myersbus bus
    41h 23m
    $380–744

Des Moines to Fort Myers by bus

Calendar5Weekly Buses
Duration36h 5mAverage Duration
Ticket$247Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Fort Myers.ExpandLaunch map view
  • Distance: 1,259.2 mi
  • Duration: 5h 9m

What companies run services between Des Moines, IA, USA and Fort Myers, FL, USA?

Allegiant Air, Southwest Airlines, and three other airlines fly from Des Moines (DSM) to Ft. Myers (RSW) every 3 hours. Alternatively, you can take a bus from Des Moines to Fort Myers Bus Stop via Indianapolis Union Station, Atlanta Bus Station, and Tampa Bus Station in around 36h 5m.

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