Rome2Rio

How to get fromDes Moines to Fort Myersby plane, bus (Greyhound, Flixbus), bus, train, car, or taxi

Find Transport to Fort Myers

See all options

There are 6 ways to get from Des Moines to Fort Myers by plane, bus (Greyhound, Flixbus), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ft. Myers

    best
    1. Fly from Des Moines (DSM) to Ft. Myers (RSW)plane plane DSM - RSW
    5h 9m
    $201–876

  2. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    32h 45m
    $246–459

  3. Bus, train

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Tampatrain train
    3. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    2d 3h
    $660–1,357

  4. Drive 1,424.2 mi

    1. Drive from Des Moines to Fort Myerscar car 1,424.2 mi
    26h 2m
    $260–376

  5. Fly to Sarasota–Bradenton International Airport, bus

    1. Fly from Des Moines (DSM) to Sarasota–Bradenton International Airport (SRQ)plane plane DSM - SRQ
    2. Take the bus from Sarasota Cattlemen Transfer Center to Fort Myers Bus Stopbus bus
    6h 30m
    $261–1,144

  6. Fly to Punta Gorda Airport, taxi

    1. Fly from Des Moines (DSM) to Punta Gorda Airport (PGD)plane plane DSM - PGD
    2. Take the taxi from Punta Gorda Airport (PGD) to Fort Myerstaxi taxi
    3h 47m
    $268–916

Des Moines to Fort Myers by bus

Calendar7Weekly Buses
Duration32h 45mAverage Duration
Ticket$246Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Fort Myers.ExpandLaunch map view
  • Distance: 1,259.2 mi
  • Duration: 5h 9m

What companies run services between Des Moines, IA, USA and Fort Myers, FL, USA?

Allegiant Air, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Ft. Myers (RSW) every 4 hours. Alternatively, you can take a bus from Des Moines to Fort Myers Bus Stop via St Louis Bus Station, Atlanta Bus Station, and Tampa Bus Station in around 32h 45m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers