There are 7 ways to get from Des Moines to Gainesville by plane, bus (Greyhound, Flixbus), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Gainesville Regional Airport
best- Fly from Des Moines (DSM) to Gainesville Regional Airport (GNV)plane DSM - GNV
6h 54m$140–623Bus
- Take the bus from Des Moines to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Gainesvillebus
27h 10m$179–335Bus, train
- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Jacksonvilletrain
- Take the bus from Jacksonville to Gainesvillebus
46h 30m$487–1,058Drive 1,198 mi
- Drive from Des Moines to Gainesvillecar 1,198 mi
21h 39m$219–316Fly to Valdosta, bus
- Fly from Des Moines (DSM) to Valdosta (VLD)plane DSM - VLD
- Take the bus from Valdosta to Gainesvillebus
8h 19m$155–662Fly to Jacksonville, bus
- Fly from Des Moines (DSM) to Jacksonville (JAX)plane DSM - JAX
- Take the bus from Jacksonville to Gainesvillebus
8h 38m$158–690Fly to Orlando Sanford, drive
- Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane DSM - SFB
- Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar
5h 21m$168–651
Des Moines to Gainesville by bus
Questions & Answers
The cheapest way to get from Des Moines to Gainesville is to bus which costs $170 - $340 and takes 27h 10m.
The fastest way to get from Des Moines to Gainesville is to fly and drive which takes 5h 21m and costs $160 - $650.
No, there is no direct bus from Des Moines to Gainesville. However, there are services departing from Des Moines and arriving at Gainesville via St Louis Bus Station and Atlanta Bus Station. The journey, including transfers, takes approximately 27h 10m.
The distance between Des Moines and Gainesville is 1057 miles. The road distance is 1204.9 miles.
The best way to get from Des Moines to Gainesville without a car is to bus which takes 27h 10m and costs $170 - $340.
It takes approximately 6h 54m to get from Des Moines to Gainesville, including transfers.
Des Moines to Gainesville bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Gainesville is to fly which takes 6h 54m and costs $140 - $650. Alternatively, you can bus, which costs $170 - $340 and takes 27h 10m.
Des Moines to Gainesville bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Gainesville is 1h ahead of Des Moines. It is currently 11:21 PM in Des Moines and 12:21 AM in Gainesville.
What companies run services between Des Moines, IA, USA and Gainesville, FL, USA?
American Airlines and Delta fly from Des Moines (DSM) to Gainesville Regional Airport (GNV) 5 times a day. Alternatively, you can take a bus from Des Moines to Gainesville via St Louis Bus Station and Atlanta Bus Station in around 27h 10m.
- Website
- delta.com
Flights from Des Moines to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 6h 21m
- When
- Every day
- Estimated price
- $120–600
Flights from Des Moines to Valdosta via Atlanta
- Ave. Duration
- 7h 14m
- When
- Every day
- Estimated price
- $110–600
Flights from Des Moines to Valdosta via Minneapolis, Atlanta
- Ave. Duration
- 9h 16m
- When
- Every day
- Estimated price
- $150–700
Flights from Des Moines to Jacksonville via Atlanta
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $130–650
Flights from Des Moines to Jacksonville via Minneapolis
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $170–750
Flights from Des Moines to Jacksonville via Detroit
- Ave. Duration
- 6h 10m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–750
- Website
- aa.com
Flights from Des Moines to Gainesville Regional Airport via Charlotte
- Ave. Duration
- 6h 6m
- When
- Thursday and Sunday
- Estimated price
- $130–650
Flights from Des Moines to Gainesville Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h
- When
- Every day
- Estimated price
- $160–750
Flights from Des Moines to Jacksonville via Charlotte
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $140–700
Flights from Des Moines to Jacksonville via Chicago O'Hare
- Ave. Duration
- 6h 42m
- When
- Every day
- Estimated price
- $150–700
- Website
- united.com
Flights from Des Moines to Jacksonville via Chicago O'Hare
- Ave. Duration
- 6h 18m
- When
- Every day
- Estimated price
- $150–700
- Website
- allegiantair.com
Flights from Des Moines to Orlando Sanford
- Ave. Duration
- 2h 44m
- When
- Friday, Monday, and Wednesday
- Estimated price
- $130–600
- Website
- southwest.com
Flights from Des Moines to Jacksonville via Chicago Midway
- Ave. Duration
- 5h 22m
- When
- Monday to Wednesday
- Estimated price
- $150–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Jacksonville
- Ave. Duration
- 34h 52m
- Frequency
- Once daily
- Estimated price
- $430–950
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 20m
- Frequency
- 5 times a week
- Estimated price
- $55–110
- Website
- Greyhound
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $80–150
- Website
- Greyhound
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $45–90
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h
- Frequency
- 5 times a week
- Estimated price
- $75–130
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Gainesville
- Ave. Duration
- 5h 10m
- Frequency
- 5 times a day
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 29m
- Frequency
- 6 times a week
- Estimated price
- $9–16
- Schedules at
- Flixbus USA
Bus from Valdosta to Gainesville
- Ave. Duration
- 2h 10m
- Frequency
- 4 times a day
- Estimated price
- $14–24
- Schedules at
- Flixbus USA
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 29m
- Frequency
- 6 times a week
- Estimated price
- $9–16
- Schedules at
- Flixbus USA
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More Questions & Answers
Yes, the driving distance between Des Moines to Gainesville is 1205 miles. It takes approximately 21h 39m to drive from Des Moines to Gainesville.
Book your Des Moines to Gainesville bus tickets online with Omio and FlixBus.
There are 273+ hotels available in Gainesville.






