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How to get fromDes Moines to Gainesvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 8 ways to get from Des Moines to Gainesville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gainesville Regional Airport

    best
    1. Fly from Des Moines (DSM) to Gainesville Regional Airport (GNV)plane plane DSM - GNV
    6h 54m
    $140–623

  2. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    28h 15m
    $198–329

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Gainesvillebus bus
    46h 30m
    $463–1,001

  4. Drive  1,198 mi

    1. Drive from Des Moines to Gainesvillecar car 1,198 mi
    21h 39m
    $219–316

  5. Fly to Valdosta, bus

    1. Fly from Des Moines (DSM) to Valdosta (VLD)plane plane DSM - VLD
    2. Take the bus from Valdosta to Gainesvillebus bus
    8h 53m
    $157–662

  6. Fly to Jacksonville, bus

    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 33m
    $159–740

  7. Fly to Orlando Sanford, drive

    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    5h 18m
    $168–701

  8. Bus, train via Atlanta

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    29h 26m
    $226–423

Des Moines to Gainesville by bus

Calendar7Weekly Buses
Duration28h 15mAverage Duration
Ticket$198Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Gainesville.ExpandLaunch map view
  • Distance: 1,050.4 mi
  • Duration: 6h 54m

What companies run services between Des Moines, IA, USA and Gainesville, FL, USA?

American Airlines and Delta fly from Des Moines (DSM) to Gainesville Regional Airport (GNV) 5 times a day. Alternatively, you can take a bus from Des Moines to Gainesville via Indianapolis Union Station and Atlanta Bus Station in around 28h 15m.

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