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How to get fromDes Moines to Gatlinburgby plane, taxi, bus, car, or train

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There are 9 ways to get from Des Moines to Gatlinburg by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    5h 37m
    $418–1,431

  2. Drive 846.8 mi

    cheapest
    1. Drive from Des Moines to Gatlinburgcar car 846.8 mi
    14h 49m
    $155–224

  3. Bus, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the bus from Indianapolis to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Gatlinburgcar car
    30h 31m

  4. Bus, train, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Gatlinburgcar car
    36h 36m

  5. Fly to Asheville Regional Airport, drive

    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Gatlinburgcar car
    6h 9m
    $163–694

  6. Fly to Nashville, drive

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Gatlinburgcar car
    5h 33m
    $163–676

  7. Bus, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the bus from Chicago to N Wilson Rd & Ferrell Pl - Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the bus from Charlotte Bus Station to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Gatlinburgcar car
    32h 51m

  8. Bus, train, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Gatlinburgcar car
    40h 19m

  9. Bus, train, drive via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Gatlinburgcar car
    42h 12m

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$230Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Gatlinburg.ExpandLaunch map view
  • Distance: 699.5 mi
  • Duration: 5h 37m

What companies run services between Des Moines, IA, USA and Gatlinburg, TN, USA?

There is no direct connection from Des Moines to Gatlinburg. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Gatlinburg. Alternatively, you can take a bus from Des Moines to Gatlinburg via Indianapolis, Indianapolis, Columbus, S 3Rd St & E Town St, E Livingston Ave & Macon Aly, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 30h 31m.

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