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How to get fromDes Moines to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 10 ways to get from Des Moines to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 21m
    $238–1,137

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 15m
    $152–693

  3. Bus, drive (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    31h 13m
    $190–371

  4. Bus, train, drive

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    41h 20m
    $451–964

  5. Drive 868.8 mi

    1. Drive from Des Moines to Great Smoky Mountainscar car 868.8 mi
    15h 41m
    $159–229

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 21m
    $232–1,006

  7. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Des Moines (DSM) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane DSM - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    6h 28m
    $203–876

  8. Fly to Nashville, drive

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    6h 24m
    $158–686

  9. Bus, train, drive via Ironville

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    32h 7m
    $234–461

  10. Bus, train, drive via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    42h 17m
    $484–993

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$216Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 719.6 mi
  • Duration: 6h 21m

What companies run services between Des Moines, IA, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Des Moines to Great Smoky Mountains. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Des Moines to Great Smoky Mountains via Indianapolis Union Station, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 31h 13m.

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