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How to get fromDes Moines to Greenvilleby bus, taxi, car, plane, or train

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There are 5 ways to get from Des Moines to Greenville by bus, taxi, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi

    best
    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    2. Take the taxi from St Louis Bus Station to Greenvilletaxi taxi
    9h 17m
    $173–258

  2. Drive 359.8 mi

    cheapest
    1. Drive from Des Moines to Greenvillecar car 359.8 mi
    7h 38m
    $66–95

  3. Fly to Lambert–St. Louis International Airport, train, taxi

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    3. Take the taxi from SHILOH-SCOTT station to Greenvilletaxi taxi
    6h 23m
    $251–944

  4. Fly to Abraham Lincoln Capital Airport, drive

    1. Fly from Des Moines (DSM) to Abraham Lincoln Capital Airport (SPI)plane plane DSM - SPI
    2. Drive from Abraham Lincoln Capital Airport (SPI) to Greenvillecar car
    5h 36m
    $121–591

  5. Fly to Decatur Airport, drive

    1. Fly from Des Moines (DSM) to Decatur Airport (DEC)plane plane DSM - DEC
    2. Drive from Decatur Airport (DEC) to Greenvillecar car
    6h 17m
    $119–595

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar134Weekly Planes
Duration5h 27mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Greenville.ExpandLaunch map view
  • Distance: 465.9 mi
  • Duration: 9h 17m

What companies run services between Des Moines, IA, USA and Greenville, IL, USA?

There is no direct connection from Des Moines to Greenville. However, you can take the bus to St Louis Bus Station then take the taxi to Greenville. Alternatively, you can drive from Des Moines to Greenville in around 7h 38m.

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