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How to get fromDes Moines to Greenvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 7 ways to get from Des Moines to Greenville by plane, bus (Greyhound, Flixbus, Amtrak), car, taxi, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    4h 30m
    $243–1,016

  2. Drive 954.2 mi

    cheapest
    1. Drive from Des Moines to Greenvillecar car 954.2 mi
    17h 25m
    $175–252

  3. Bus via Carbondale

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    25h 30m
    $211–455

  4. Fly to Asheville Regional Airport, taxi

    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    5h 10m
    $278–841

  5. Fly to Columbia, drive

    1. Fly from Des Moines (DSM) to Columbia (CAE)plane plane DSM - CAE
    2. Drive from Columbia-Airport-CAE to Greenvillecar car
    6h 27m
    $376–1,749

  6. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    26h 15m
    $211–450

  7. Bus #2

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    27h 38m
    $216–466

Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) flights

Calendar79Weekly Planes
Duration5h 33mAverage Duration
Ticket$197Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Greenville.ExpandLaunch map view
  • Distance: 789.8 mi
  • Duration: 4h 30m

What companies run services between Des Moines, IA, USA and Greenville, SC, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a bus from Des Moines to Greenville via St Louis Bus Station, Carbondale Intermodal Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 25h 30m.

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