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How to get fromDes Moines to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Des Moines to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville

    best
    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    6h 27m
    $179–774

  2. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    28h 35m
    $218–427

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    43h 56m
    $556–1,205

  4. Drive 1,177.5 mi

    1. Drive from Des Moines to Jacksonvillecar car 1,177.5 mi
    22h 14m
    $215–311

  5. Fly to Brunswick Golden Isles Airport, bus

    1. Fly from Des Moines (DSM) to Brunswick Golden Isles Airport (BQK)plane plane DSM - BQK
    2. Take the bus from Brunswick to Jacksonvillebus bus
    7h 6m
    $184–758

  6. Fly to Orlando Sanford, drive

    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    5h 21m
    $200–806

Des Moines to Jacksonville by bus

Calendar7Weekly Buses
Duration28h 35mAverage Duration
Ticket$218Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Jacksonville.ExpandLaunch map view
  • Distance: 1,037.1 mi
  • Duration: 6h 27m

What companies run services between Des Moines, IA, USA and Jacksonville, FL, USA?

American Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Jacksonville (JAX) every 2 hours. Alternatively, you can take a bus from Des Moines to Jacksonville via St Louis Bus Station and Atlanta Bus Station in around 28h 35m.

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