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How to get fromDes Moines to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 8 ways to get from Des Moines to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Albert J. Ellis Airport

    best
    1. Fly from Des Moines (DSM) to Albert J. Ellis Airport (OAJ)plane plane DSM - OAJ
    5h 4m
    $168–711

  2. Fly to Greenville, bus

    cheapest
    1. Fly from Des Moines (DSM) to Greenville (PGV)plane plane DSM - PGV
    2. Take the bus from Greenville GK Butterfield Trans Ctr to Jacksonville Bus Stopbus bus
    8h 24m
    $158–707

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Jacksonville Bus Stopbus bus
    35h 35m
    $211–434

  4. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Wilsontrain train
    5. Take the bus from Wilson Bus Stop to Jacksonville Bus Stopbus bus
    37h 30m
    $415–883

  5. Drive 1,180.4 mi

    1. Drive from Des Moines to Jacksonvillecar car 1,180.4 mi
    20h 56m
    $216–312

  6. Fly to Wilmington International Airport, bus

    1. Fly from Des Moines (DSM) to Wilmington International Airport (ILM)plane plane DSM - ILM
    2. Take the bus from Wilmington Amtrak Station to Jacksonville Amtrak Bus Stopbus bus
    7h
    $178–712

  7. Fly to Coastal Carolina Regional Airport, bus

    1. Fly from Des Moines (DSM) to Coastal Carolina Regional Airport (EWN)plane plane DSM - EWN
    2. Take the bus from New Bern to Jacksonville Bus Stopbus bus
    6h 46m
    $186–798

  8. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Jacksonville Bus Stopbus bus
    37h 58m
    $408–851

Des Moines to Jacksonville by bus

Calendar7Weekly Buses
Duration35h 35mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Jacksonville.ExpandLaunch map view
  • Distance: 1,005.3 mi
  • Duration: 5h 4m

What companies run services between Des Moines, IA, USA and Jacksonville, NC, USA?

American Airlines and Delta fly from Des Moines (DSM) to Albert J. Ellis Airport (OAJ) every 4 hours. Alternatively, you can take a bus from Des Moines to Jacksonville Bus Stop via Chicago Bus Station, Washington Union Station, and Raleigh Bus Station in around 35h 35m.

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