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How to get fromDes Moines to Jefferson Cityby bus (Greyhound), car, plane, bus, train, or shuttle

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There are 6 ways to get from Des Moines to Jefferson City by bus (Greyhound), car, plane, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to Jefferson Citybus bus Greyhound US0175s
    7h 48m
    $84–128

  2. Drive 255.3 mi

    cheapest
    1. Drive from Des Moines to Jefferson Citycar car 255.3 mi
    5h 11m
    $47–68

  3. Fly Des Moines to Columbia Regional Airport

    1. Fly from Des Moines (DSM) to Columbia Regional Airport (COU)plane plane DSM - COU
    4h 41m
    $208–731

  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the train from Kansas City to Jefferson City Stationtrain train Missouri River Runner / ...
    8h 17m
    $103–182

  5. Fly Des Moines to Lambert–St. Louis International Airport, shuttle

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take a shuttle bus from St Louis International Airport to Jefferson City, Missourishuttle bus
    7h
    $293–971

  6. Drive to Fort Dodge Municipal Airport, fly to Columbia Regional Airport

    1. Drive from Des Moines to Fort Dodge Municipal Airport (FOD)car car
    2. Fly from Fort Dodge Municipal Airport (FOD) to Columbia Regional Airport (COU)plane plane FOD - COU
    13h 54m
    $177–504

Des Moines to Jefferson City by bus, foot, and train

Calendar14Weekly Services
Duration8h 17mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Jefferson City.ExpandLaunch map view
  • Distance: 346.7 mi
  • Duration: 7h 48m

What companies run services between Des Moines, IA, USA and Jefferson City, MO, USA?

You can take a bus from Des Moines to Jefferson City via Kansas City, Kansas City Bus Station, and Jefferson City in around 7h 48m. Alternatively, American Airlines and United Airlines fly from Des Moines (DSM) to Columbia Regional Airport (COU) every 3 hours.

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