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How to get fromDes Moines to Jefferson Cityby bus (Greyhound), car, plane, bus, train, or shuttle

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There are 6 ways to get from Des Moines to Jefferson City by bus (Greyhound), car, plane, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the bus from Kansas City Bus Station to Jefferson Citybus bus Greyhound US0175s
    7h 33m
    $70–103

  2. Drive  255.3 mi

    cheapest
    1. Drive from Des Moines to Jefferson Citycar car 255.3 mi
    5h 12m
    $44–63

  3. Fly to Columbia Regional Airport

    1. Fly from Des Moines (DSM) to Columbia Regional Airport (COU)plane plane DSM - COU
    5h 5m
    $174–513

  4. Bus, train

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the train from Kansas City to Jefferson City Stationtrain train Missouri River Runner / ...
    8h 3m
    $120–192

  5. Bus, train via Des Moines

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the train from Kansas City to Jefferson City Stationtrain train Missouri River Runner / ...
    8h 17m
    $138–212

  6. Fly to Lambert–St. Louis International Airport, shuttle

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take a shuttle bus from St Louis International Airport to Jefferson City, Missourishuttle bus
    7h 20m
    $239–673

Des Moines to Jefferson City by bus, foot, and train

Calendar7Weekly Services
Duration8h 3mAverage Duration
Ticket$120Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Jefferson City.ExpandLaunch map view
  • Distance: 347.1 mi
  • Duration: 7h 33m

What companies run services between Des Moines, IA, USA and Jefferson City, MO, USA?

You can take a bus from Des Moines to Jefferson City via Kansas City Bus Station and Jefferson City in around 7h 33m. Alternatively, United Airlines and American Airlines fly from Des Moines (DSM) to Columbia Regional Airport (COU) every 4 hours.

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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