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How to get fromDes Moines to Kentuckyby plane, bus (Greyhound, Amtrak), bus, train, car, taxi, or bus (Greyhound)

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There are 8 ways to get from Des Moines to Kentucky by plane, bus (Greyhound, Amtrak), bus, train, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Covington

    best
    1. Fly from Des Moines (DSM) to Covington (CVG)plane plane DSM - CVG
    4h 32m
    $160–823

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    13h 5m
    $94–178

  3. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    17h 44m
    $164–344

  4. Drive 579.9 mi

    1. Drive from Des Moines to Louisvillecar car 579.9 mi
    9h 44m
    $106–153

  5. Fly to Louisville International Airport

    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    5h 7m
    $149–774

  6. Fly to Evansville, taxi

    1. Fly from Des Moines (DSM) to Evansville (EVV)plane plane DSM - EVV
    2. Take the taxi from Evansville (EVV) to Owensborotaxi taxi
    5h 19m
    $208–681

  7. Fly to Blue Grass Airport

    1. Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane plane DSM - LEX
    6h 42m
    $230–1,223

  8. Bus via Speedway

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis to El Mercadito Grocery - Clarksville, INbus bus Indianapolis
    15h 11m
    $120–278

Des Moines to Kentucky by bus

Calendar7Weekly Buses
Duration13h 5mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Kentucky.ExpandLaunch map view
  • Distance: 524.1 mi
  • Duration: 4h 32m

What companies run services between Des Moines, IA, USA and Kentucky, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Covington (CVG) hourly. Alternatively, you can take a bus from Des Moines to Louisville, KY via Indianapolis Union Station in around 13h 5m.

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