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How to get fromDes Moines to Key Largoby plane, shuttle, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Key Largo

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There are 6 ways to get from Des Moines to Key Largo by plane, shuttle, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Miami International Airport, shuttle

    best
    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)plane plane DSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    5h 44m
    $219–633

  2. Fly to Key West International Airport, bus

    cheapest
    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)plane plane DSM - EYW
    2. Take the bus from Key West Airport to Key Largo Bus Stopbus bus
    9h 35m
    $126–469

  3. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    38h 40m
    $288–479

  4. Bus, train, shuttle

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    2d 9h
    $1,284–2,047

  5. Drive  1,571 mi

    1. Drive from Des Moines to Key Largocar car 1,571 mi
    28h 30m
    $287–415

  6. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    6h 1m
    $249–723

Des Moines to Key Largo by bus

Calendar7Weekly Buses
Duration38h 40mAverage Duration
Ticket$288Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Key Largo.ExpandLaunch map view
  • Distance: 1,392.1 mi
  • Duration: 5h 44m

What companies run services between Des Moines, IA, USA and Key Largo, FL, USA?

You can take a bus from Des Moines to Key Largo Bus Stop via Indianapolis Union Station, Atlanta Bus Station, and Miami Airport Station in around 38h 40m.

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