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How to get fromDes Moines to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Des Moines to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    4h 14m
    $314–1,493

  2. Fly to Chattanooga Metropolitan Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Chattanooga Metropolitan Airport (CHA)plane plane DSM - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 51m
    $147–701

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 51m
    $392–569

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 59m
    $742–1,189

  5. Drive  812.4 mi

    1. Drive from Des Moines to Knoxvillecar car 812.4 mi
    13h 52m
    $149–215

  6. Fly to Nashville, drive

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 35m
    $149–723

  7. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 57m
    $404–582

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 48m
    $769–1,173

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar59Weekly Planes
Duration5h 7mAverage Duration
Ticket$241Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Knoxville.ExpandLaunch map view
  • Distance: 673.2 mi
  • Duration: 4h 14m

What companies run services between Des Moines, IA, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Des Moines to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 41h 51m.

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