Rome2Rio

How to get fromDes Moines to Knoxvilleby plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

Find Transport to Knoxville

See all options

There are 9 ways to get from Des Moines to Knoxville by plane, bus (Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    4h 46m
    $303–1,291

  2. Drive 812.4 mi

    cheapest
    1. Drive from Des Moines to Knoxvillecar car 812.4 mi
    13h 52m
    $149–215

  3. Bus

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    37h 51m

  4. Bus, train

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 4m

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Des Moines (DSM) to Chattanooga Metropolitan Airport (CHA)plane plane DSM - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 3m
    $276–1,249

  6. Fly to Nashville, drive

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 35m
    $158–671

  7. Fly to Asheville Regional Airport, drive

    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 23m
    $170–706

  8. Bus, train via Ossining

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    41h 41m

  9. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 57m

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$230Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Knoxville.ExpandLaunch map view
  • Distance: 673.2 mi
  • Duration: 4h 46m

What companies run services between Des Moines, IA, USA and Knoxville, TN, USA?

United Airlines, Delta, and American Airlines fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Des Moines to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 37h 51m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers