Rome2Rio

How to get fromDes Moines to La Crosseby plane, bus, car, or train

Find Transport to La Crosse

See all options

There are 5 ways to get from Des Moines to La Crosse by plane, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Des Moines (DSM) to La Crosse (LSE)plane plane DSM - LSE
    4h 45m
    $132–594

  2. Drive 238.9 mi

    cheapest
    1. Drive from Des Moines to La Crossecar car 238.9 mi
    5h 1m
    $44–63

  3. Bus

    1. Take the bus from Des Moines to Albert Leabus bus
    2. Take the bus from Albert Lea to Rochesterbus bus
    3. Take the bus from Rochester, MN to La Crossebus bus
    8h 5m

  4. Fly to Rochester, bus

    1. Fly from Des Moines (DSM) to Rochester (RST)plane plane DSM - RST
    2. Take the bus from Rochester, MN to La Crossebus bus
    7h 59m
    $121–531

  5. Bus, train

    1. Take the bus from Des Moines to St. Paulbus bus Jefferson Lines 802 / ...
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train Empire Builder / ...
    8h 27m
    $105–174

Des Moines (DSM) to La Crosse (LSE) flights

Calendar44Weekly Planes
Duration6h 30mAverage Duration
Ticket$98Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to La Crosse.ExpandLaunch map view
  • Distance: 216.4 mi
  • Duration: 4h 45m

What companies run services between Des Moines, IA, USA and La Crosse, WI, USA?

American Airlines, Allegiant Air, and United Airlines fly from Des Moines (DSM) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Des Moines to La Crosse via Albert Lea and Rochester, MN in around 8h 5m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers