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How to get fromDes Moines to La Crosseby plane, bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Des Moines to La Crosse by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Des Moines (DSM) to La Crosse (LSE)plane plane DSM - LSE
    4h 22m
    $98–406

  2. Drive  238.9 mi

    cheapest
    1. Drive from Des Moines to La Crossecar car 238.9 mi
    5h 1m
    $43–61

  3. Bus, train

    1. Take the bus from Des Moines to St. Paulbus bus Jefferson Lines 806 / ...
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train Empire Builder / ...
    8h 27m
    $135–199

  4. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Des Moines (DSM) to Minneapolis–Saint Paul International Airport (MSP)plane plane DSM - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    5h 53m
    $146–536

  5. Fly to Rochester, bus

    1. Fly from Des Moines (DSM) to Rochester (RST)plane plane DSM - RST
    2. Take the bus from Rochester to La Crossebus bus
    7h 45m
    $98–433

  6. Bus

    1. Take the bus from Des Moines to St. Paulbus bus Jefferson Lines 806 / ...
    2. Take the bus from St. Paul to La Crossebus bus Jefferson Lines 965
    9h
    $105–154

  7. Bus via Minneapolis

    1. Take the bus from Des Moines to Minneapolis Bus Stationbus bus Greyhound US0156
    2. Take the bus from Minneapolis to La Crossebus bus Jefferson Lines 965
    9h 35m
    $90–132

Des Moines to La Crosse by bus and train

Calendar11Weekly Services
Duration8h 27mAverage Duration
Ticket$135Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to La Crosse.ExpandLaunch map view
  • Distance: 216.4 mi
  • Duration: 4h 22m

What companies run services between Des Moines, IA, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Des Moines to La Crosse via St. Paul in around 9h.

Airlines
Train operators
Bus operators

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