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How to get fromDes Moines to Lexingtonby plane, car, or bus

Find Transport to Lexington

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There are 5 ways to get from Des Moines to Lexington by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    4h 57m
    $173–894

  2. Bus, drive

    cheapest
    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    15h 53m
    $109–182

  3. Drive  648.5 mi

    1. Drive from Des Moines to Lexingtoncar car 648.5 mi
    11h 15m
    $119–171

  4. Fly to Covington, drive

    1. Fly from Des Moines (DSM) to Covington (CVG)plane plane DSM - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    5h 3m
    $174–895

  5. Fly to Blue Grass Airport

    1. Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane plane DSM - LEX
    6h 54m
    $111–575

Des Moines (DSM) to Louisville International Airport (SDF) flights

Calendar123Weekly Planes
Duration5h 13mAverage Duration
Ticket$148Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Lexington.ExpandLaunch map view
  • Distance: 564.9 mi
  • Duration: 4h 57m

What companies run services between Des Moines, IA, USA and Lexington, KY, USA?

United Airlines, American Airlines, and Delta fly from Des Moines (DSM) to Blue Grass Airport (LEX) hourly.

Airlines
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