What is the cheapest way to get from Des Moines to Louisville?

The cheapest way to get from Des Moines to Louisville is to drive which costs $100 - $160 and takes 9h 44m.

What is the fastest way to get from Des Moines to Louisville?

The fastest way to get from Des Moines to Louisville is to fly which takes 4h 59m and costs $150 - $850.

Is there a direct bus between Des Moines and Louisville?

No, there is no direct bus from Des Moines to Louisville station. However, there are services departing from Des Moines and arriving at Louisville Bus Station via Indianapolis Union Station. The journey, including transfers, takes approximately 12h 20m.

How far is it from Des Moines to Louisville?

The distance between Des Moines and Louisville is 494 miles. The road distance is 583.3 miles.

How do I travel from Des Moines to Louisville without a car?

The best way to get from Des Moines to Louisville without a car is to bus which takes 12h 20m and costs $130 - $200.

How long does it take to get from Des Moines to Louisville?

It takes approximately 4h 59m to get from Des Moines to Louisville, including transfers.

Where do I catch the Des Moines to Louisville bus from?

Des Moines to Louisville bus services, operated by Jefferson Lines, depart from Des Moines station.

Bus or fly from Des Moines to Louisville?

The best way to get from Des Moines to Louisville is to fly which takes 4h 59m and costs $150 - $850. Alternatively, you can bus, which costs $130 - $200 and takes 12h 20m.

Where does the Des Moines to Louisville bus arrive?

Des Moines to Louisville bus services, operated by Jefferson Lines, arrive at Indianapolis station.

What is the time difference between Des Moines and Louisville?

Louisville is 1h ahead of Des Moines. It is currently 10:15 AM in Des Moines and 11:15 AM in Louisville.

Can I drive from Des Moines to Louisville?

Yes, the driving distance between Des Moines to Louisville is 583 miles. It takes approximately 9h 44m to drive from Des Moines to Louisville.

How do I get a bus ticket from Des Moines to Louisville?

Book your Des Moines to Louisville bus tickets online with Omio.

Where can I stay near Louisville?

There are 551+ hotels available in Louisville.

Des Moines to Louisville - 5 ways to travel via train, plane, bus, and car

How to get fromDes Moines to Louisville

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There are 5 ways to get from Des Moines to Louisville by plane, bus (Greyhound, Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to Louisville International Airport
best
1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane DSM - SDF
4h 59m
$159–824
Drive 579.9 mi
cheapest
1. Drive from Des Moines to Louisvillecar 579.9 mi
9h 44m
$106–153
Bus
1. Take the bus from Des Moines to Indianapolisbus Btw 1402
2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus Greyhound US0100 / ...
12h 20m
$130–198
Bus, train
1. Take the bus from Des Moines to Galesburgbus
2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
3. Take the train from Chicago Union Station to Indianapolistrain
4. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus
17h 9m
$187–366
Fly to Blue Grass Airport, drive
1. Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane DSM - LEX
2. Drive from Lexington-Airport-LEX to Louisvillecar
5h 48m
$261–1,240

Des Moines to Louisville by bus

7Weekly Buses

12h 20mAverage Duration

$130Cheapest Price

See schedules

Questions & Answers

Map of how to get from Des Moines to Louisville.

Launch map view

Distance: 491.6 mi
Duration: 4h 59m

What companies run services between Des Moines, IA, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Des Moines to Louisville Bus Station via Indianapolis Union Station in around 12h 20m.

Airlines

Train operators

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