There are 6 ways to get from Des Moines to Mayo Clinic by bus, car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Des Moines to St. Paulbus Jefferson Lines 806 / ...
- Take the bus from St. Paul to Rochesterbus Jefferson Lines 965
7h 11m$93–129Drive 207.7 mi
cheapest- Drive from Des Moines to Mayo Cliniccar 207.7 mi
3h 28m$37–53Fly to Rochester
- Fly from Des Moines (DSM) to Rochester (RST)plane DSM - RST
5h 22m$70–393Bus via Minneapolis
- Take the bus from Des Moines to Minneapolis Bus Stationbus Greyhound US0156
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus Groome Transportation
8h 15m$97–118Bus via Minneapolis #2
- Take the bus from Des Moines to Minneapolisbus Jefferson Lines 804 / ...
- Take the bus from Minneapolis to Rochesterbus Jefferson Lines 965
9h 6m$95–135Fly to Minneapolis–Saint Paul International Airport, bus
- Fly from Des Moines (DSM) to Minneapolis–Saint Paul International Airport (MSP)plane DSM - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
4h 35m$124–473
Des Moines to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Des Moines to Mayo Clinic is to drive which costs $35 - $55 and takes 3h 28m.
The fastest way to get from Des Moines to Mayo Clinic is to drive which takes 3h 28m and costs $35 - $55.
No, there is no direct bus from Des Moines to Mayo Clinic. However, there are services departing from Des Moines and arriving at Rochester via St. Paul. The journey, including transfers, takes approximately 7h 11m.
The distance between Des Moines and Mayo Clinic is 332 miles. The road distance is 208.9 miles.
The best way to get from Des Moines to Mayo Clinic without a car is to bus which takes 7h 11m and costs $90 - $130.
It takes approximately 7h 11m to get from Des Moines to Mayo Clinic, including transfers.
Des Moines to Mayo Clinic bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Des Moines to Mayo Clinic is to bus which takes 7h 11m and costs $90 - $130. Alternatively, you can fly, which costs $70 - $400 and takes 5h 22m.
Des Moines to Mayo Clinic bus services, operated by Jefferson Lines, arrive at St. Paul station.
Yes, the driving distance between Des Moines to Mayo Clinic is 209 miles. It takes approximately 3h 28m to drive from Des Moines to Mayo Clinic.
What companies run services between Des Moines, IA, USA and Mayo Clinic, MN, USA?
You can take a bus from Des Moines to Mayo Clinic via St. Paul and Rochester in around 7h 11m. Alternatively, Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Rochester (RST) every 4 hours.
- Website
- delta.com
Flights from Des Moines to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $50–330
Flights from Des Moines to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $55–400
- Website
- aa.com
Flights from Des Moines to Rochester via Chicago O'Hare
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $65–370
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 40m
- Frequency
- Twice daily
- Estimated price
- $60–90
- Book at
- Jefferson Lines
- Adult
- $60–90
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Bus from Des Moines to Minneapolis
- Ave. Duration
- 5h 45m
- Frequency
- 3 times a day
- Estimated price
- $65–90
- Book at
- Jefferson Lines
- Adult
- $65–90
Bus from Minneapolis to Rochester
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $30–45
- Book at
- Jefferson Lines
- Adult
- $30–45
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to Minneapolis Bus Station
- Ave. Duration
- 4h 25m
- Frequency
- Once daily
- Estimated price
- $45–70
- Website
- Greyhound
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
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Booking & Getting There
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