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How to get fromDes Moines to Mechanicsburgby plane, bus (Flixbus), bus, train, car, taxi, or bus (Greyhound)

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There are 9 ways to get from Des Moines to Mechanicsburg by plane, bus (Flixbus), bus, train, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Des Moines (DSM) to Harrisburg International Airport (MDT)plane plane DSM - MDT
    6h 26m
    $150–725

  2. Bus

    1. Take the bus from Des Moines to Chicagobus bus Btw 1202 / ...
    2. Take the bus from Chicago Bus Station to Harrisburg Bus Stationbus bus FlixBus N2640 / ...
    24h 9m

  3. Bus, train

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    24h 13m

  4. Drive 964.9 mi

    1. Drive from Des Moines to Mechanicsburgcar car 964.9 mi
    15h 57m
    $177–255

  5. Fly to Lancaster, taxi

    1. Fly from Des Moines (DSM) to Lancaster (LNS)plane plane DSM - LNS
    2. Take the taxi from Lancaster-Airport-LNS to Mechanicsburgtaxi taxi
    6h 20m
    $288–891

  6. Fly to Philadelphia International Airport, train

    1. Fly from Des Moines (DSM) to Philadelphia International Airport (PHL)plane plane DSM - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    7h 4m
    $252–1,096

  7. Fly to Penn State University Park Airport, bus

    1. Fly from Des Moines (DSM) to Penn State University Park Airport (SCE)plane plane DSM - SCE
    2. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    8h 36m
    $164–699

  8. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Harrisburg Bus Stationbus bus Greyhound US0421
    25h 39m
    $157–306

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    4. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    26h 19m

Des Moines (DSM) to Harrisburg International Airport (MDT) flights

Calendar102Weekly Planes
Duration5h 50mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Mechanicsburg.ExpandLaunch map view
  • Distance: 912 mi
  • Duration: 6h 26m

What companies run services between Des Moines, IA, USA and Mechanicsburg, Cumberland County, PA, USA?

Delta, Allegiant Air, and two other airlines fly from Des Moines (DSM) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Des Moines to E Main St & Arch St WB via Chicago Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 24h 9m.

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