There are 4 ways to get from Des Moines to Mesa by plane, bus, train, bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Des Moines (DSM) to Phoenix (PHX)plane DSM - PHX
4h 9m$170–773Bus, train
- Take the bus from Des Moines to Kansas Citybus
- Take the train from Kansas City to Flagstafftrain
- Take the bus from Flagstaff Train Station to Tempebus
33h 23m$479–965Bus
- Take the bus from Des Moines to Denver Union Stationbus
- Take the bus from Denver to El Paso Bus Stationbus
- Take the bus from El Paso Bus Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus
38h$281–472Drive 1,380.2 mi
- Drive from Des Moines to Mesacar 1,380.2 mi
24h 4m$252–364
Des Moines to Mesa by bus and foot
Questions & Answers
The cheapest way to get from Des Moines to Mesa is to drive which costs $250 - $370 and takes 24h 4m.
The fastest way to get from Des Moines to Mesa is to fly which takes 4h 9m and costs $170 - $800.
No, there is no direct bus from Des Moines to Mesa. However, there are services departing from Des Moines and arriving at University Dr & Mesa Dr via 11th St & Auraria Pkwy, Denver, El Paso Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station and University Dr & Rural Rd. The journey, including transfers, takes approximately 38h.
The distance between Des Moines and Mesa is 1174 miles. The road distance is 1388.2 miles.
The best way to get from Des Moines to Mesa without a car is to bus and train which takes 33h 23m and costs $470 - $1,000.
It takes approximately 4h 9m to get from Des Moines to Mesa, including transfers.
Des Moines to Mesa bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Mesa is to fly which takes 4h 9m and costs $170 - $800. Alternatively, you can bus, which costs $280 - $480 and takes 38h.
Des Moines to Mesa bus services, operated by Greyhound USA, arrive at Denver Union Station.
Mesa is 2h behind Des Moines. It is currently 11:33 PM in Des Moines and 9:33 PM in Mesa.
What companies run services between Des Moines, IA, USA and Mesa, AZ, USA?
American Airlines, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Phoenix (PHX) every 3 hours. Alternatively, you can take a bus from Des Moines to University Dr & Mesa Dr via Denver Union Station, 11th St & Auraria Pkwy, Stout St & 21st St, Denver, El Paso Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tempe, and University Dr & Rural Rd in around 38h.
- Website
- aa.com
Flights from Des Moines to Phoenix
- Ave. Duration
- 2h 59m
- When
- Every day
- Estimated price
- $150–750
Flights from Des Moines to Phoenix via Dallas/Ft.Worth
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $190–850
- Website
- southwest.com
Flights from Des Moines to Phoenix
- Ave. Duration
- 3h
- When
- Sunday
- Estimated price
- $150–750
Flights from Des Moines to Phoenix via Denver
- Ave. Duration
- 4h 58m
- When
- Tuesday, Wednesday, Sunday, and Saturday
- Estimated price
- $160–750
Flights from Des Moines to Phoenix via Las Vegas
- Ave. Duration
- 5h 10m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $190–850
- Website
- united.com
Flights from Des Moines to Phoenix via Denver
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $160–750
- Website
- delta.com
Flights from Des Moines to Phoenix via Minneapolis
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $190–850
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to Flagstaff
- Ave. Duration
- 23h 52m
- Frequency
- Once daily
- Estimated price
- $400–850
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–75
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Flagstaff Train Station to Tempe
- Ave. Duration
- 2h 50m
- Frequency
- 5 times a week
- Estimated price
- $24–40
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Des Moines to Denver Union Station
- Ave. Duration
- 14h 25m
- Frequency
- Once daily
- Estimated price
- $110–210
- Website
- https://www.greyhound.com/
Bus from El Paso Bus Station to Phoenix Sky Harbor Airport/44th Street Sky Train Station
- Ave. Duration
- 9h 5m
- Frequency
- Once daily
- Estimated price
- $65–120
- Website
- https://www.greyhound.com/
- Phone
- +1 800-923-1799
- [email protected]
- Website
- omnibusexpress.com
Bus from Denver to El Paso Bus Station
- Ave. Duration
- 9h 45m
- Frequency
- 4 times a day
- Estimated price
- $100–140
- Schedules at
- omnibusexpress.com
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Des Moines to Mesa is 1388 miles. It takes approximately 24h 4m to drive from Des Moines to Mesa.
There are 2158+ hotels available in Mesa.














