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How to get fromDes Moines to Mesaby plane, bus, train, car, or bus (Greyhound)

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There are 6 ways to get from Des Moines to Mesa by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Phoenix

    best
    1. Fly from Des Moines (DSM) to Phoenix (PHX)plane plane DSM - PHX
    4h 10m
    $141–405

  2. Fly to Phoenix-Mesa Gateway Airport

    cheapest
    1. Fly from Des Moines (DSM) to Phoenix-Mesa Gateway Airport (AZA)plane plane DSM - AZA
    5h 15m
    $125–509

  3. Bus via Ciudad Juárez

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from 2745 Southwest Blvd - Kansas City to El Pasobus bus
    3. Take the bus from El Paso to Phoenixbus bus
    32h 31m
    $255–359

  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to Flagstafftrain train
    3. Take the bus from Flagstaff Train Station to Tempebus bus
    33h 23m
    $729–1,214

  5. Drive  1,380.2 mi

    1. Drive from Des Moines to Mesacar car 1,380.2 mi
    24h 4m
    $252–364

  6. Bus

    1. Take the bus from Des Moines to Tulsabus bus Jefferson Lines 801
    2. Take the bus from Tulsa Bus Station to Phoenix Bus Stationbus bus Greyhound US1210
    35h 2m
    $308–447

Des Moines to Mesa by bus, foot, and tram

Calendar7Weekly Services
Duration32h 31mAverage Duration
Ticket$255Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Mesa.ExpandLaunch map view
  • Distance: 1,167.3 mi
  • Duration: 4h 10m

What companies run services between Des Moines, IA, USA and Mesa, AZ, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Phoenix (PHX) every 3 hours. Alternatively, you can take a bus from Des Moines to Mesa Dr/Main St via Kansas City, On 12Th At Troost Westbound Farside, On Southwest Blvd At 27Th St Southbound, 2745 Southwest Blvd - Kansas City, El Paso, El Paso, Phoenix, and 24th St/Jefferson in around 32h 31m.

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