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How to get fromDes Moines to Milwaukeeby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Des Moines to Milwaukee by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to General Mitchell International Airport (MKE)plane plane DSM - MKE
    4h 4m
    $131–774

  2. Drive 355.5 mi

    cheapest
    1. Drive from Des Moines to Milwaukeecar car 355.5 mi
    6h 25m
    $65–94

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    9h 43m
    $80–151

  4. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150 / ...
    9h 45m
    $65–122

  5. Bus via Milwaukee Mitchell Airport

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Milwaukee Mitchell Airportbus bus FlixBus 2548 / ...
    10h 20m
    $67–120

  6. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    10h 54m
    $110–224

Des Moines to Milwaukee by bus, foot, and train

Calendar19Weekly Services
Duration9h 43mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Milwaukee.ExpandLaunch map view
  • Distance: 323.4 mi
  • Duration: 4h 4m

What companies run services between Des Moines, IA, USA and Milwaukee, WI, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to General Mitchell International Airport (MKE) hourly. Alternatively, you can take a bus from Des Moines to Milwaukee Intermodal Station via Chicago Bus Station in around 9h 45m.

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