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How to get fromDes Moines to Milwaukeeby plane, bus, train, car, or bus (Greyhound, Flixbus)

Find Transport to Milwaukee

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There are 6 ways to get from Des Moines to Milwaukee by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to General Mitchell International Airport (MKE)plane plane DSM - MKE
    4h 7m
    $117–676

  2. Drive  355.5 mi

    cheapest
    1. Drive from Des Moines to Milwaukeecar car 355.5 mi
    6h 25m
    $65–94

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    9h 43m
    $72–132

  4. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150
    9h 45m
    $65–104

  5. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    10h 54m
    $92–196

  6. Bus via Rochester

    1. Take the bus from Des Moines to Owatonnabus bus
    2. Take the bus from Owatonna to Rochesterbus bus
    3. Take the bus from Rochester to Milwaukeebus bus
    12h 40m
    $127–211

Des Moines to Milwaukee by bus, foot, and train

Calendar19Weekly Services
Duration9h 43mAverage Duration
Ticket$72Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Milwaukee.ExpandLaunch map view
  • Distance: 323.4 mi
  • Duration: 4h 7m

What companies run services between Des Moines, IA, USA and Milwaukee, WI, USA?

Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to General Mitchell International Airport (MKE) hourly. Alternatively, you can take a bus from Des Moines to Milwaukee Intermodal Station via Chicago Bus Station in around 9h 45m.

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