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How to get fromDes Moines to Mississippiby plane, bus (Greyhound), bus, train, or car

Find Transport to Mississippi

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There are 8 ways to get from Des Moines to Mississippi by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Memphis

    best
    1. Fly from Des Moines (DSM) to Memphis (MEM)plane plane DSM - MEM
    4h 8m
    $260–1,148

  2. Drive 803.6 mi

    cheapest
    1. Drive from Des Moines to Jacksoncar car 803.6 mi
    14h 17m
    $147–212

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Jacksonbus bus
    19h 25m
    $198–297

  4. Bus, train

    1. Take the bus from Des Moines to Champaignbus bus Btw 1402
    2. Take the train from Champaign-Urbana to Jacksontrain train City of New Orleans
    21h 5m
    $283–524

  5. Fly to Gulfport-Biloxi Regional Airport

    1. Fly from Des Moines (DSM) to Gulfport-Biloxi Regional Airport (GPT)plane plane DSM - GPT
    5h
    $209–885

  6. Fly to Jackson/Vicksburg

    1. Fly from Des Moines (DSM) to Jackson/Vicksburg (JAN)plane plane DSM - JAN
    5h
    $208–771

  7. Fly to Meridian

    1. Fly from Des Moines (DSM) to Meridian (MEI)plane plane DSM - MEI
    5h 26m
    $203–840

  8. Bus via St. Louis

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    2. Take the bus from St Louis Bus Station to Jacksonbus bus Greyhound US1173
    21h 5m
    $178–287

Des Moines to Mississippi by bus and train

Calendar7Weekly Services
Duration21h 5mAverage Duration
Ticket$283Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Mississippi.ExpandLaunch map view
  • Distance: 504.3 mi
  • Duration: 4h 8m

What companies run services between Des Moines, IA, USA and Mississippi, USA?

Delta, American Airlines, and two other airlines fly from Des Moines (DSM) to Memphis (MEM) hourly. Alternatively, you can take a bus from Des Moines to Jackson via Kansas City and Memphis Bus Station in around 19h 25m.

Airlines
Train operators
Bus operators

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