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How to get fromDes Moines to Mississippiby plane, bus, train, bus (Greyhound), or car

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There are 7 ways to get from Des Moines to Mississippi by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Memphis

    best
    1. Fly from Des Moines (DSM) to Memphis (MEM)plane plane DSM - MEM
    4h 39m
    $220–998

  2. Drive  803.6 mi

    cheapest
    1. Drive from Des Moines to Jacksoncar car 803.6 mi
    14h 17m
    $147–212

  3. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus Greyhound US0157S
    2. Take the train from Champaign-Urbana to Jacksontrain train City of New Orleans
    21h 10m
    $213–468

  4. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Jacksonbus bus
    21h 15m
    $163–297

  5. Fly to Gulfport-Biloxi Regional Airport

    1. Fly from Des Moines (DSM) to Gulfport-Biloxi Regional Airport (GPT)plane plane DSM - GPT
    5h 24m
    $179–785

  6. Fly to Jackson/Vicksburg

    1. Fly from Des Moines (DSM) to Jackson/Vicksburg (JAN)plane plane DSM - JAN
    4h 59m
    $178–671

  7. Fly to Meridian

    1. Fly from Des Moines (DSM) to Meridian (MEI)plane plane DSM - MEI
    5h 23m
    $163–690

Des Moines to Mississippi by bus and train

Calendar7Weekly Services
Duration21h 10mAverage Duration
Ticket$213Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Mississippi.ExpandLaunch map view
  • Distance: 504.3 mi
  • Duration: 4h 39m

What companies run services between Des Moines, IA, USA and Mississippi, USA?

Delta, American Airlines, and two other airlines fly from Des Moines (DSM) to Memphis (MEM) hourly. Alternatively, you can take a bus from Des Moines to Jackson via Kansas City, Kansas City Bus Station, and St Louis Bus Station in around 21h 15m.

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