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How to get fromDes Moines to Mount Vernonby bus (Greyhound), car, plane, or bus

Find Transport to Mount Vernon

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There are 5 ways to get from Des Moines to Mount Vernon by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    2. Take the bus from St Louis Bus Station to Mount Vernonbus bus Greyhound US0185 / ...
    10h 45m
    $83–151

  2. Drive 407.2 mi

    cheapest
    1. Drive from Des Moines to Mount Vernoncar car 407.2 mi
    7h 58m
    $75–108

  3. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the bus from St Louis Bus Station to Mount Vernonbus bus
    7h 8m
    $181–857

  4. Fly to Evansville, bus

    1. Fly from Des Moines (DSM) to Evansville (EVV)plane plane DSM - EVV
    2. Take the bus from Evansville Bus Station to Mount Vernonbus bus
    7h 21m
    $160–633

  5. Fly to Nashville, bus

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Take the bus from Nashville Bus Station to Mount Vernonbus bus
    8h 25m
    $164–704

Des Moines (DSM) to Lambert–St. Louis International Airport (STL) flights

Calendar134Weekly Planes
Duration5h 27mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Mount Vernon.ExpandLaunch map view
  • Distance: 494.2 mi
  • Duration: 10h 45m

What companies run services between Des Moines, IA, USA and Mount Vernon, IL, USA?

You can take a bus from Des Moines to Mount Vernon via St Louis Bus Station and Mount Vernon in around 10h 45m.

Airlines
Bus operators

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Need to know: Greyhound

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