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How to get fromDes Moines to Murphysboroby plane, bus, train, car, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound, Amtrak, Flixbus)

Find Transport to Murphysboro

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There are 6 ways to get from Des Moines to Murphysboro by plane, bus, train, car, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport

    best
    1. Fly from Des Moines (DSM) to Williamson County Regional Airport (MWA)plane plane DSM - MWA
    5h 42m
    $124–443

  2. Drive  415.2 mi

    cheapest
    1. Drive from Des Moines to Murphysborocar car 415.2 mi
    8h 30m
    $74–106

  3. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus Greyhound US0157S
    2. Take the train from Champaign-Urbana to Carbondaletrain train City of New Orleans / ...
    11h 19m
    $177–276

  4. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    7h 44m
    $141–622

  5. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    11h 30m
    $132–188

  6. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    13h 47m

Des Moines (DSM) to Williamson County Regional Airport (MWA) flights

Calendar21Weekly Planes
Duration7h 5mAverage Duration
Ticket$64Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Murphysboro.ExpandLaunch map view
  • Distance: 385.6 mi
  • Duration: 5h 42m

What companies run services between Des Moines, IA, USA and Murphysboro, IL, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to Williamson County Regional Airport (MWA) 3 times a day. Alternatively, you can take a bus from Des Moines to Murphysboro via Kansas City, Kansas City Bus Station, St Louis Bus Station, and Carbondale Intermodal Station in around 11h 30m.

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