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How to get fromDes Moines to Murphysboroby plane, car, bus (Greyhound, Amtrak, Flixbus), bus, or train

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There are 7 ways to get from Des Moines to Murphysboro by plane, car, bus (Greyhound, Amtrak, Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barkley Regional Airport, drive

    best
    1. Fly from Des Moines (DSM) to Barkley Regional Airport (PAH)plane plane DSM - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    6h 32m
    $131–642

  2. Drive 415.2 mi

    cheapest
    1. Drive from Des Moines to Murphysborocar car 415.2 mi
    8h 30m
    $76–110

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    11h 25m
    $100–196

  4. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    7h 54m
    $195–947

  5. Fly to Williamson County Regional Airport

    1. Fly from Des Moines (DSM) to Williamson County Regional Airport (MWA)plane plane DSM - MWA
    4h 35m
    $163–681

  6. Fly to Nashville, bus

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    7h 35m
    $169–701

  7. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus Greyhound US0157S
    2. Take the train from Champaign-Urbana to Carbondaletrain train City of New Orleans / ...
    11h 29m
    $133–244

Des Moines (DSM) to Barkley Regional Airport (PAH) flights

Calendar23Weekly Planes
Duration5h 55mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Murphysboro.ExpandLaunch map view
  • Distance: 487.2 mi
  • Duration: 6h 32m

What companies run services between Des Moines, IA, USA and Murphysboro, IL, USA?

You can take a bus from Des Moines to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 11h 25m. Alternatively, United Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Williamson County Regional Airport (MWA) 3 times a day.

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