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How to get fromDes Moines to Murphysboroby plane, bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

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There are 7 ways to get from Des Moines to Murphysboro by plane, bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport

    best
    1. Fly from Des Moines (DSM) to Williamson County Regional Airport (MWA)plane plane DSM - MWA
    4h 35m
    $153–581

  2. Drive  415.2 mi

    cheapest
    1. Drive from Des Moines to Murphysborocar car 415.2 mi
    8h 30m
    $76–110

  3. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus Greyhound US0157S
    2. Take the train from Champaign-Urbana to Carbondaletrain train City of New Orleans / ...
    11h 29m
    $118–223

  4. Fly to Barkley Regional Airport, drive

    1. Fly from Des Moines (DSM) to Barkley Regional Airport (PAH)plane plane DSM - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    7h 2m
    $116–522

  5. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    7h 41m
    $154–737

  6. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St. Louis to Carbondalebus bus
    11h 40m
    $121–200

  7. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    4. Take the bus from St. Louis to Carbondalebus bus
    13h 57m
    $112–193

Des Moines (DSM) to Williamson County Regional Airport (MWA) flights

Calendar28Weekly Planes
Duration5h 52mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Murphysboro.ExpandLaunch map view
  • Distance: 385.6 mi
  • Duration: 4h 35m

What companies run services between Des Moines, IA, USA and Murphysboro, IL, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to Williamson County Regional Airport (MWA) 4 times a day. Alternatively, you can take a bus from Des Moines to Murphysboro via Kansas City, Kansas City Bus Station, St Louis Bus Station, St. Louis, and Carbondale in around 11h 40m.

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