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How to get fromDes Moines to Myrtle Beachby plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Des Moines to Myrtle Beach by plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Myrtle Beach (MYR)plane plane DSM - MYR
    4h 40m
    $149–635

  2. Bus via Carbondale

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    30h
    $206–403

  3. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Wilsontrain train
    5. Take the bus from Wilson to Wilmington Amtrak Stationbus bus
    6. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    39h 45m
    $465–939

  4. Drive 1,183.1 mi

    1. Drive from Des Moines to Myrtle Beachcar car 1,183.1 mi
    21h 17m
    $216–312

  5. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    30h 35m
    $206–403

  6. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    43h 58m
    $475–991

Des Moines to Myrtle Beach by bus

Calendar5Weekly Buses
Duration30hAverage Duration
Ticket$206Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Myrtle Beach.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 4h 40m

What companies run services between Des Moines, IA, USA and Myrtle Beach, SC, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Myrtle Beach (MYR) every 4 hours. Alternatively, you can take a bus from Des Moines to Myrtle Beach Bus Station via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, and Atlanta Bus Station in around 30h.

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