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How to get fromDes Moines to Myrtle Beachby plane, bus (Greyhound), bus, train, or car

Find Transport to Myrtle Beach

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There are 5 ways to get from Des Moines to Myrtle Beach by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Myrtle Beach (MYR)plane plane DSM - MYR
    4h 29m
    $110–447

  2. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    31h 30m
    $242–360

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    38h 22m
    $648–1,100

  4. Drive  1,183.6 mi

    1. Drive from Des Moines to Myrtle Beachcar car 1,183.6 mi
    21h 16m
    $216–312

  5. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Fayetteville Amtrak Stationtrain train
    5. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    38h 25m
    $754–1,194

Des Moines to Myrtle Beach by bus (Greyhound)

Calendar7Weekly Buses
Duration31h 30mAverage Duration
Ticket$242Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Myrtle Beach.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 4h 29m

What companies run services between Des Moines, IA, USA and Myrtle Beach, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Myrtle Beach (MYR) every 4 hours. Alternatively, you can take a bus from Des Moines to Myrtle Beach Bus Station via Indianapolis Union Station and Atlanta Bus Station in around 31h 30m.

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Need to know: Greyhound

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