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How to get fromDes Moines to Myrtle Beachby plane, bus (Greyhound), bus, train, or car

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There are 6 ways to get from Des Moines to Myrtle Beach by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Myrtle Beach (MYR)plane plane DSM - MYR
    4h 34m
    $129–585

  2. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    31h 45m
    $208–344

  3. Bus, train via Wilson

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Wilsontrain train
    5. Take the bus from Wilson to Wilmington Amtrak Stationbus bus
    6. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    39h 45m
    $389–840

  4. Drive  1,183.1 mi

    1. Drive from Des Moines to Myrtle Beachcar car 1,183.1 mi
    21h 17m
    $216–312

  5. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    5. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    41h 6m
    $422–941

  6. Bus, train #2

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    44h 7m
    $406–856

Des Moines to Myrtle Beach by bus (Greyhound)

Calendar7Weekly Buses
Duration31h 45mAverage Duration
Ticket$208Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Myrtle Beach.ExpandLaunch map view
  • Distance: 979 mi
  • Duration: 4h 34m

What companies run services between Des Moines, IA, USA and Myrtle Beach, SC, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Myrtle Beach (MYR) every 4 hours. Alternatively, you can take a bus from Des Moines to Myrtle Beach Bus Station via Indianapolis Union Station and Atlanta Bus Station in around 31h 45m.

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