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How to get fromDes Moines to Naplesby plane, bus, bus (Greyhound, Flixbus), train, or car

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There are 6 ways to get from Des Moines to Naples by plane, bus, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, bus

    best
    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take the bus from Fort Lauderdale Airport to Naples, FLbus bus
    6h 9m
    $244–898

  2. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to University of South Floridabus bus
    4. Take the bus from University of South Florida - 3801 USF Holly Dr to Naples, FLbus bus
    34h 26m
    $281–527

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Orlandotrain train
    3. Take the bus from Orlando to Fort Myers Amtrak Bus Stopbus bus
    4. Take the bus from Fort Myers 7-11 to Naples, FLbus bus
    2d 7h
    $707–1,451

  4. Drive 1,457.9 mi

    1. Drive from Des Moines to Naplescar car 1,457.9 mi
    26h 39m
    $267–385

  5. Fly to Sarasota–Bradenton International Airport, bus

    1. Fly from Des Moines (DSM) to Sarasota–Bradenton International Airport (SRQ)plane plane DSM - SRQ
    2. Take the bus from Bradenton/Sarasota - Mobil Gas Station to Naples, FLbus bus
    7h 36m
    $289–1,107

  6. Fly to Ft. Myers, line 240 bus, line 600 bus, line 11 bus

    1. Fly from Des Moines (DSM) to Ft. Myers (RSW)plane plane DSM - RSW
    2. Take the bus from South Fort Myers Transfer/P&R to Coconut Point Mallbus bus
    3. Take the bus from Coconut Point Mall to Creekside Way Transfer @ Immokalee Rdbus bus
    4. Take the bus from Creekside WLinC to 3rd Ave Sbus bus
    8h 57m

Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL) flights

Calendar54Weekly Planes
Duration5h 48mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Naples.ExpandLaunch map view
  • Distance: 1,430.5 mi
  • Duration: 6h 9m

What companies run services between Des Moines, IA, USA and Naples, FL, USA?

You can take a bus from Des Moines to Naples via St Louis Bus Station, Atlanta Bus Station, University of South Florida - 3801 USF Holly Dr, and Naples, FL in around 34h 26m.

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