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How to get fromDes Moines to Natchezby plane, bus, train, car, or taxi

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There are 9 ways to get from Des Moines to Natchez by plane, bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Natchez

    best
    1. Fly from Des Moines (DSM) to Natchez (HEZ)plane plane DSM - HEZ
    7h 6m
    $176–656

  2. Drive 801.6 mi

    cheapest
    1. Drive from Des Moines to Natchezcar car 801.6 mi
    15h 52m
    $147–212

  3. Bus, train, drive via Champaign

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to Brookhaven Stationtrain train
    3. Drive from Brookhaven Station to Natchezcar car
    23h 28m
    $251–541

  4. Bus, train, drive

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to Brookhaven Stationtrain train
    4. Drive from Brookhaven Station to Natchezcar car
    24h 14m
    $157–306

  5. Fly to Alexandria International Airport, taxi

    1. Fly from Des Moines (DSM) to Alexandria International Airport (AEX)plane plane DSM - AEX
    2. Take the taxi from Alexandria International Airport (AEX) to Natcheztaxi taxi
    6h 40m
    $150–647

  6. Fly to Baton Rouge Metropolitan Airport, drive

    1. Fly from Des Moines (DSM) to Baton Rouge Metropolitan Airport (BTR)plane plane DSM - BTR
    2. Drive from Baton-Rouge-Airport-BTR to Natchezcar car
    6h 30m
    $153–644

  7. Fly to Monroe Regional Airport, taxi

    1. Fly from Des Moines (DSM) to Monroe Regional Airport (MLU)plane plane DSM - MLU
    2. Take the taxi from Monroe Regional Airport (MLU) to Natcheztaxi taxi
    6h 38m
    $150–647

  8. Fly to Lafayette Regional Airport, taxi

    1. Fly from Des Moines (DSM) to Lafayette Regional Airport (LFT)plane plane DSM - LFT
    2. Take the taxi from Lafayette Regional Airport (LFT) to Natcheztaxi taxi
    7h 51m
    $160–647

  9. Fly to Jackson/Vicksburg, train, drive

    1. Fly from Des Moines (DSM) to Jackson/Vicksburg (JAN)plane plane DSM - JAN
    2. Take the train from Jackson to Brookhaven Stationtrain train
    3. Drive from Brookhaven Station to Natchezcar car
    8h 15m
    $204–723

Des Moines (DSM) to Natchez (HEZ) flights

Calendar14Weekly Planes
Duration6h 46mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Natchez.ExpandLaunch map view
  • Distance: 714.4 mi
  • Duration: 7h 6m

What companies run services between Des Moines, IA, USA and Natchez, MS, USA?

United Airlines and American Airlines fly from Des Moines (DSM) to Natchez (HEZ) twice daily.

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