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How to get fromDes Moines to O'Fallonby bus (Greyhound), bus, train, car, or plane

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There are 5 ways to get from Des Moines to O'Fallon by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    10h 7m
    $102–146

  2. Drive  345.7 mi

    cheapest
    1. Drive from Des Moines to O'Falloncar car 345.7 mi
    6h 58m
    $60–86

  3. Bus, train via Kansas City

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    12h 10m
    $189–296

  4. Fly, train

    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    6h 26m
    $108–527

  5. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus Greyhound US0157S
    2. Take the train from Bloomington-Normal to St. Louistrain train Lincoln Service / ...
    11h 32m
    $142–221

Des Moines to O'Fallon by bus and train

Calendar18Weekly Services
Duration10h 7mAverage Duration
Ticket$102Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to O'Fallon.ExpandLaunch map view
  • Distance: 464.7 mi
  • Duration: 10h 7m

What companies run services between Des Moines, IA, USA and O'Fallon, IL, USA?

You can take a bus from Des Moines to State @ Lincoln Eb via Kansas City, Kansas City Bus Station, St Louis Bus Station, CIVIC CENTER station, FAIRVIEW HEIGHTS station, and Fairview Heights Transit Center in around 10h 7m.

Airlines
Train operators
Bus operators

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Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound