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How to get fromDes Moines to Ohioby plane, bus (Greyhound), car, bus, bus (Greyhound, Flixbus), or train

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There are 10 ways to get from Des Moines to Ohio by plane, bus (Greyhound), car, bus, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Cleveland-Hopkins International Airport

    best
    1. Fly from Des Moines (DSM) to Cleveland-Hopkins International Airport (CLE)plane plane DSM - CLE
    4h 14m
    $171–874

  2. Fly to Akron

    cheapest
    1. Fly from Des Moines (DSM) to Akron (CAK)plane plane DSM - CAK
    5h 44m
    $93–421

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Columbusbus bus Greyhound US0421
    15h 20m
    $100–188

  4. Drive 619.4 mi

    1. Drive from Des Moines to Columbuscar car 619.4 mi
    11h 28m
    $113–164

  5. Fly to John Glenn Columbus International Airport

    1. Fly from Des Moines (DSM) to John Glenn Columbus International Airport (CMH)plane plane DSM - CMH
    4h 47m
    $170–874

  6. Fly to Covington

    1. Fly from Des Moines (DSM) to Covington (CVG)plane plane DSM - CVG
    5h 9m
    $161–826

  7. Fly to Dayton

    1. Fly from Des Moines (DSM) to Dayton (DAY)plane plane DSM - DAY
    5h 47m
    $270–1,423

  8. Fly to Detroit, bus

    1. Fly from Des Moines (DSM) to Detroit (DTW)plane plane DSM - DTW
    2. Take the bus from Dearborn to Toledobus bus
    5h 24m
    $172–767

  9. Bus via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Columbusbus bus FlixBus 2511 / ...
    15h 25m
    $107–191

  10. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Toledotrain train
    4. Take the bus from Toledo to Columbus - Mound Stbus bus
    17h 14m
    $178–369

Des Moines to Ohio by bus (Greyhound)

Calendar7Weekly Buses
Duration15h 20mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Ohio.ExpandLaunch map view
  • Distance: 629.4 mi
  • Duration: 4h 14m

What companies run services between Des Moines, IA, USA and Ohio, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Cleveland-Hopkins International Airport (CLE) hourly. Alternatively, you can take a bus from Des Moines to Columbus via Indianapolis Union Station in around 15h 20m.

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