Rome2Rio

How to get fromDes Moines to Panama City Beachby plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound)

Find Transport to Panama City Beach

See all options

There are 7 ways to get from Des Moines to Panama City Beach by plane, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    5h 5m
    $208–786

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS)plane plane DSM - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 26m
    $158–687

  3. Bus via St. Louis

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    5. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    30h 49m
    $213–427

  4. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to New Orleans Union Passenger Terminaltrain train
    3. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    4. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    33h 21m
    $366–756

  5. Drive 1,061.1 mi

    1. Drive from Des Moines to Panama City Beachcar car 1,061.1 mi
    19h 57m
    $194–280

  6. Fly to Dothan Regional Airport, drive

    1. Fly from Des Moines (DSM) to Dothan Regional Airport (DHN)plane plane DSM - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    6h 51m
    $165–697

  7. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    32h 4m
    $215–416

Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) flights

Calendar55Weekly Planes
Duration5h 59mAverage Duration
Ticket$144Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Panama City Beach.ExpandLaunch map view
  • Distance: 913.1 mi
  • Duration: 5h 5m

What companies run services between Des Moines, IA, USA and Panama City Beach, FL, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) every 4 hours. Alternatively, you can take a bus from Des Moines to Panama City Beach via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, Atlanta Bus Station, Tallahassee, and Panama City Beach Bus Station in around 30h 49m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers