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How to get fromDes Moines to Panama Cityby plane or car

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There are 6 ways to get from Des Moines to Panama City by plane or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    5h 11m
    $203–701

  2. Fly to Pensacola International Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Pensacola International Airport (PNS)plane plane DSM - PNS
    2. Drive from Pensacola-Airport-PNS to Panama Citycar car
    7h 32m
    $137–600

  3. Drive 1,056.8 mi

    1. Drive from Des Moines to Panama Citycar car 1,056.8 mi
    19h 52m
    $193–279

  4. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS)plane plane DSM - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    5h 39m
    $140–639

  5. Fly to Dothan Regional Airport, drive

    1. Fly from Des Moines (DSM) to Dothan Regional Airport (DHN)plane plane DSM - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    6h 45m
    $144–645

  6. Fly to Tallahassee, drive

    1. Fly from Des Moines (DSM) to Tallahassee (TLH)plane plane DSM - TLH
    2. Drive from Tallahassee (TLH) to Panama Citycar car
    6h 43m
    $185–847

Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) flights

Calendar55Weekly Planes
Duration5h 59mAverage Duration
Ticket$124Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Panama City.ExpandLaunch map view
  • Distance: 917.3 mi
  • Duration: 5h 11m

What companies run services between Des Moines, IA, USA and Panama City, FL, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) every 4 hours.

Airlines

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