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How to get fromDes Moines to Pensacolaby plane, taxi, bus, train, bus (Greyhound), or car

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There are 7 ways to get from Des Moines to Pensacola by plane, taxi, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Destin–Fort Walton Beach Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS)plane plane DSM - VPS
    2. Take the taxi from Destin–Fort Walton Beach Airport (VPS) to Pensacolataxi taxi
    3h 37m
    $259–823

  2. Fly to Pensacola International Airport

    cheapest
    1. Fly from Des Moines (DSM) to Pensacola International Airport (PNS)plane plane DSM - PNS
    5h 38m
    $111–505

  3. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Pensacolabus bus
    30h 15m
    $343–800

  4. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Opelika 4th Street Stationbus bus
    4. Take the bus from Opelika 4th Street Station to Mobilebus bus
    5. Take the bus from Loxley to Pensacolabus bus
    31h 27m
    $280–426

  5. Drive  1,012.2 mi

    1. Drive from Des Moines to Pensacolacar car 1,012.2 mi
    19h 9m
    $185–267

  6. Fly to Northwest Florida Beaches International Airport, drive

    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Pensacolacar car
    6h 38m
    $167–750

  7. Fly to Mobile Regional Airport, bus

    1. Fly from Des Moines (DSM) to Mobile Regional Airport (MOB)plane plane DSM - MOB
    2. Take the bus from Mobile to Pensacolabus bus
    6h 53m
    $219–818

Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar38Weekly Planes
Duration4h 34mAverage Duration
Ticket$122Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Pensacola.ExpandLaunch map view
  • Distance: 913.8 mi
  • Duration: 3h 37m

What companies run services between Des Moines, IA, USA and Pensacola, FL, USA?

You can take a bus from Des Moines to Pensacola via Indianapolis Union Station, Montgomery Intermodal Center, Opelika 4th Street Station, and Loxley in around 31h 27m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Pensacola International Airport (PNS) every 2 hours.

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