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How to get fromDes Moines to Port Saint Lucieby plane, bus, bus (Greyhound, Flixbus), train, car, or taxi

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There are 7 ways to get from Des Moines to Port Saint Lucie by plane, bus, bus (Greyhound, Flixbus), train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, bus

    best
    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DSM - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 4m
    $228–866

  2. Fly to Orlando Sanford, drive

    cheapest
    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    5h 29m
    $192–806

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Port St Luciebus bus
    34h 19m
    $239–450

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    2d 2h
    $633–1,338

  5. Drive 1,421.2 mi

    1. Drive from Des Moines to Port Saint Luciecar car 1,421.2 mi
    25h 8m
    $260–375

  6. Fly to Melbourne International Airport, taxi, bus

    1. Fly from Des Moines (DSM) to Melbourne International Airport (MLB)plane plane DSM - MLB
    2. Take the taxi from Melbourne International Airport (MLB) to Sebastiantaxi taxi
    3. Take the bus from Sebastian to Port St Luciebus bus
    9h 54m
    $269–894

  7. Fly to President Donald J. Trump International Airport, bus

    1. Fly from Des Moines (DSM) to President Donald J. Trump International Airport (PBI)plane plane DSM - PBI
    2. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    9h 29m
    $217–938

Des Moines to Port Saint Lucie by bus

Calendar7Weekly Buses
Duration34h 19mAverage Duration
Ticket$239Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,420.8 mi
  • Duration: 7h 4m

What companies run services between Des Moines, IA, USA and Port Saint Lucie, FL, USA?

You can take a bus from Des Moines to SW PSL Blvd & SE Bayshore Blvd via St Louis Bus Station, Atlanta Bus Station, and SW Gatlin Blvd & SW Brescia St in around 34h 19m.

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